SCHEMBL522908

SCHEMBL522908

O=C(O)c1cccc(/N=N/O)c1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.57
RAB9A P51151 5/20 0.57
NPC1 O15118 4/20 0.57
SMN1; SMN2 Q16637 4/20 0.57
KMT2A Q03164 3/20 0.55
ALDH1A1 P00352 2/20 0.55
POLB P06746 2/20 0.55
L3MBTL1 Q9Y468 2/20 0.55
MEN1 O00255 2/20 0.55
GAA P10253 1/20 0.55
THRB P10828 1/20 0.55
PLCG1 P19174 1/20 0.55
KDM4E B2RXH2 1/20 0.55
APEX1 P27695 1/20 0.55
RECQL P46063 1/20 0.55
TDP1 Q9NUW8 1/20 0.55
LMNA P02545 1/20 0.54
GLA P06280 1/20 0.51
CCNE2 O96020 1/20 0.51
CCNE1 P24864 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL522910 1.00 MAPT (0.57) MAPTRAB9ANPC1SMN1; SMN2KMT2A
SCHEMBL31045928 0.90 RAB9A (0.65) MAPTRAB9ANPC1SMN1; SMN2KMT2A
SCHEMBL69866 0.90 RAB9A (0.65) MAPTRAB9ANPC1SMN1; SMN2KMT2A
SCHEMBL69865 0.90 RAB9A (0.65) MAPTRAB9ANPC1SMN1; SMN2KMT2A
SCHEMBL5486185 0.86 TRPA1 (0.67) MAPTRAB9ANPC1SMN1; SMN2KMT2A
SCHEMBL14437429 0.86 TRPA1 (0.67) MAPTRAB9ANPC1SMN1; SMN2KMT2A
Benzoic Acid SCHEMBL3860616 0.83 TRPA1 (0.69) MAPTRAB9ANPC1KMT2AALDH1A1
SCHEMBL23554009 0.82 RAB9A (0.55) MAPTRAB9ANPC1SMN1; SMN2KMT2A
SCHEMBL28545671 0.82 KMT2A (0.51) MAPTRAB9ANPC1SMN1; SMN2KMT2A
SCHEMBL21887187 0.81 CA12 (0.68) MAPTRAB9ANPC1SMN1; SMN2KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 217 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12466894-B2 Anti-MUC16 antibodies and uses thereof MEMORIAL SLOAN KETTERING CANCER CENTER (US) 2025-11-11 US claimed
CN-111579772-B Detection reagent based on immunomagnetic bead method, preparation method thereof, kit and detection method 珠海丽珠试剂股份有限公司 2022-04-08 CN claimed
CN-111579772-A Detection reagent based on immunomagnetic bead method, preparation method thereof, kit and detection method 珠海丽珠试剂股份有限公司 2020-08-25 CN claimed
EP-1920065-B1 ANTI-ALPHA V BETA 6 ANTIBODIES AND USES THEREOF BIOGEN MA INC (US) 2018-08-29 EP claimed
EP-2087008-A1 TREATMENT AND PREVENTION OF CHRONIC ASTHMA USING ANTAGONISTS OF INTEGRIN alphaVbeta6 The Regents of the University of California (US) 2009-08-12 EP claimed
EP-1920065-A4 ANTI-ALPHA V BETA 6 ANTIBODIES AND USES THEREOF BIOGEN IDEC INC (US) 2009-07-15 EP claimed
EP-2046374-A2 COMPOSITIONS AND METHODS FOR INHIBITING GROWTH OF SMAD4-DEFICIENT CANCERS Biogen Idec MA, Inc. (US) 2009-04-15 EP claimed
WO-2008147434-A9 TREATMENT AND PREVENTION OF CHRONIC ASTHMA USING ANTAGONISTS OF INTEGRIN αVβ6 UNIV CALIFORNIA (US) 2009-03-05 WO claimed
US-20080317667-A1 Compositions and methods for inhibiting growth of smad4-deficient cancers BIOGEN IDEC MA INC. (US) 2008-12-25 US claimed
WO-2008147434-A1 TREATMENT AND PREVENTION OF CHRONIC ASTHMA USING ANTAGONISTS OF INTEGRIN αVβ6 THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2008-12-04 WO claimed
EP-1920065-A2 ANTI-ALPHA V BETA 6 ANTIBODIES AND USES THEREOF Biogen Idec MA Inc. (US) 2008-05-14 EP claimed
WO-2008008315-A2 COMPOSITIONS AND METHODS FOR INHIBITING GROWTH OF SMAD4-DEFICIENT CANCERS BIOGEN IDEC MA INC. (US) 2008-01-17 WO claimed
WO-2007008712-A2 ANTI-ALPHA V BETA 6 ANTIBODIES AND USES THEREOF BIOGEN IDEC MA INC. (US) 2007-01-18 WO claimed
US-12630632-B2 Bispecific HER2 and CD3 binding molecules MEMORIAL SLOAN KETTERING CANCER CENTER (US) 2026-05-19 US disclosed
US-12617866-B2 Humanized antibodies to mucin-16 and methods of use thereof MEMORIAL SLOAN KETTERING CANCER CENTER (US) 2026-05-05 US disclosed
US-12612456-B2 CD19 antibodies and methods of using the same MEMORIAL SLOAN KETTERING CANCER CENTER (US) 2026-04-28 US disclosed
EP-1920065-A2 ANTI-ALPHA V BETA 6 ANTIBODIES AND USES THEREOF Biogen Idec MA Inc. (US) 2008-05-14 EP disclosed
WO-2008008315-A2 COMPOSITIONS AND METHODS FOR INHIBITING GROWTH OF SMAD4-DEFICIENT CANCERS BIOGEN IDEC MA INC. (US) 2008-01-17 WO disclosed
WO-2007008712-A2 ANTI-ALPHA V BETA 6 ANTIBODIES AND USES THEREOF BIOGEN IDEC MA INC. (US) 2007-01-18 WO disclosed
WO-2001094910-A2 METHOD FOR THE QUALITATIVE AND QUANTITATIVE ANALYSIS OF COMPLEX MIXTURES OF CHEMICAL COMPOUNDS, USING MALDI-TOF MASS SPECTROMETRY BASF AKTIENGESELLSCHAFT (DE) 2001-12-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12630632-B2 Bispecific HER2 and CD3 binding molecules CD274, PDCD1LG2, CD2 MAPT 1326/4885RAB9A 2781/4885NPC1 4727/4885
US-12617866-B2 Humanized antibodies to mucin-16 and methods of use thereof MUC1, IGLV6-57, IGSF11 MAPT 4535/4885RAB9A 4385/4885NPC1 4131/4885
US-12612456-B2 CD19 antibodies and methods of using the same CD74, CD4, CD2 MAPT 4220/4885RAB9A 2744/4885NPC1 1812/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.