Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 1/20 | 0.49 |
| ▸ | IDH1 | O75874 | 4/20 | 0.45 |
| ▸ | KDM1A | O60341 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 3/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5230151 | 0.76 | CES1 (0.73) | CES1KDM1ACA2CA1CA12 | |
| SCHEMBL5237280 | 0.75 | CES1 (0.49) | CES1IDH1MAPTMEN1KMT2A | |
| SCHEMBL5229246 | 0.74 | MEN1 (0.52) | CES1IDH1CA2CA1MAPT | |
| SCHEMBL5228114 | 0.73 | ALDH1A1 (0.71) | CES1IDH1KDM1ACA2CA1 | |
| SCHEMBL5228629 | 0.73 | IDH1 (0.51) | CES1IDH1MAPTNPSR1MEN1 | |
| SCHEMBL23832701 | 0.72 | IDH1 (0.54) | CES1IDH1CA2CA1MAPT | |
| SCHEMBL30218156 | 0.72 | IDH1 (0.54) | CES1IDH1CA2CA1MAPT | |
| SCHEMBL18228 | 0.72 | ALDH1A1 (0.36) | CA2CA1CA12CA9MEN1 | |
| SCHEMBL7580547 | 0.71 | IDH1 (0.71) | IDH1MCL1 | |
| SCHEMBL5228023 | 0.71 | CA2 (0.49) | CA2CA1CA12CA9MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1519932-B1 | BISARYLSULFONAMIDE COMPOUNDS AND THEIR USE IN CANCER THERAPY | CYCLACEL LTD (GB) | 2007-10-03 | — | — | EP | claimed |
| EP-1519932-B1 | BISARYLSULFONAMIDE COMPOUNDS AND THEIR USE IN CANCER THERAPY | CYCLACEL LTD (GB) | 2007-10-03 | — | — | EP | disclosed |