Sugi Predict

Sugi Predict / Compounds / SCHEMBL5229398

SCHEMBL5229398

SCHEMBL5229398

COC(=O)C1(Cc2ccccn2)CN(C(=O)OC(C)(C)C)CCN1C(=O)OCc1ccccc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 2/20 0.43
▸ KMT2A Q03164 2/20 0.43
▸ ACHE P22303 1/20 0.41
▸ MAPT P10636 1/20 0.40
▸ GRIN2B Q13224 2/20 0.39
▸ OPRD1 P41143 1/20 0.39
▸ OPRK1 P41145 1/20 0.39
▸ POLB P06746 1/20 0.39
▸ HTT P42858 1/20 0.38
▸ KDM4E B2RXH2 1/20 0.38
▸ ALDH1A1 P00352 1/20 0.38
▸ NPC1 O15118 1/20 0.38
▸ RAB9A P51151 1/20 0.38
▸ SMN1; SMN2 Q16637 1/20 0.38
▸ YAP1 P46937 1/20 0.38
▸ GPR119 Q8TDV5 2/20 0.38
▸ L3MBTL1 Q9Y468 1/20 0.38
▸ CCNT1 O60563 1/20 0.37
▸ CCNA2 P20248 1/20 0.37
▸ CDK2 P24941 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5231362 0.89 MEN1 (0.44) MEN1KMT2AHTTNPC1RAB9A
SCHEMBL6699701 0.87 GPR119 (0.41) ACHEPOLBKDM4EALDH1A1GPR119
SCHEMBL5928261 0.85 MEN1 (0.44) MEN1KMT2AACHEMAPTHTT
SCHEMBL3498514 0.85 MEN1 (0.43) MEN1KMT2AACHEMAPTHTT
SCHEMBL5230102 0.84 P2RX7 (0.46) MEN1KMT2AHTT
SCHEMBL5228286 0.83 MEN1 (0.42) MEN1KMT2AACHEMAPTGRIN2B
SCHEMBL3498570 0.83 MEN1 (0.42) MEN1KMT2AACHEMAPTHTT
SCHEMBL19839528 0.82 JAK2 (0.42) MEN1KMT2AACHEMAPTHTT
SCHEMBL5227957 0.81 MEN1 (0.40) MEN1KMT2AACHEMAPTGRIN2B
SCHEMBL5227961 0.81 MEN1 (0.40) MEN1KMT2AACHEMAPTGRIN2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1001970-B1 DIPEPTIDE DERIVATIVES AS GROWTH HORMONE SECRETAGOGUES PFIZER (US) 2007-03-07 — — EP disclosed
US-6953791-B2 Dipeptide derivatives PFIZER, INC. (US) 2005-10-11 — — US disclosed
US-6951850-B2 Dipeptide derivatives PFIZER, INC. (US) 2005-10-04 — — US disclosed
US-6924280-B2 Dipeptide derivatives PFIZER INC. (US) 2005-08-02 — — US disclosed
EP-1002802-B1 Dipeptide derivatives as growth hormone secretagogues PFIZER PROD INC (US) 2004-12-08 — — EP disclosed
US-RE38524-E1 Dipeptide derivatives as growth hormone secretagogues PFIZER INC. 2004-06-01 — — US disclosed
EP-0995748-B1 Growth hormone secretagogues PFIZER PROD INC (US) 2004-03-31 — — EP disclosed
US-6686359-B2 ANIMAL GROWTH REGULATORS; OSTEOPOROSIS; CONGESTIVE HEART FAILURE; MUSCULAR DISORDERS PFIZER INC. 2004-02-03 — — US disclosed
US-20040009984-A1 Increasing levels of endogenous growth hormone, especially treating osterporosis, aging frailty or congestive heart failure CARPINO PHILIP ALBERT (US) 2004-01-15 — — US disclosed
US-20040006063-A1 Dipeptide derivatives CARPINO PHILIP ALBERT (US) 2004-01-08 — — US disclosed
US-20020042415-A1 Dipeptide derivatives CARPINO PHILIP ALBERT (US) 2002-04-11 — — US disclosed
US-6358951-B1 ADMINISTERING PYRAZOLO(4,3-C)PYRIDINE DERIVATIVE TO TREAT OBESITY, CONGESTIVE HEART FAILURE, OSTEOPOROSIS, AGING, BONE AND MUSCULAR DISORDERS PFIZER INC. 2002-03-19 — — US disclosed
US-20020002165-A1 Dipeptide derivatives CARPINO PHILIP ALBERT (US) 2002-01-03 — — US disclosed
US-20010041703-A1 Dipeptide derivatives CARPINO PHILIP ALBERT (US) 2001-11-15 — — US disclosed
US-6251902-B1 Dipeptide derivatives as growth hormone secretagogues PFIZER INC. 2001-06-26 — — US disclosed
US-6194578-B1 GROWTH HORMONE SECRETAGOGUES; USEFUL FOR PROPHYLAXIS AND THERAPY OF OSTEOPOROSIS AND/OR FRAILTY, INSULIN RESISTANCE IN MAMMALS, CONGESTIVE HEART FAILURE, OBESITY, ACCELERATING BONE FRACTURE REPAIR REDUCING CACHEXIA AND PROTEIN LOSS PFIZER INC. 2001-02-27 — — US disclosed
EP-1001970-A1 DIPEPTIDE DERIVATIVES AS GROWTH HORMONE SECRETAGOGUES PFIZER INC. (US) 2000-05-24 — — EP disclosed
EP-1002802-A1 Dipeptide derivatives as growth hormone secretagogues Pfizer Products Inc. (US) 2000-05-24 — — EP disclosed
EP-0995748-A1 Growth hormone secretagogues Pfizer Products Inc. (US) 2000-04-26 — — EP disclosed
WO-1998058947-A1 DIPEPTIDE DERIVATIVES AS GROWTH HORMONE SECRETAGOGUES PFIZER INC. (US) 1998-12-30 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040009984-A1 Increasing levels of endogenous growth hormone, especially treating osterporosis, aging frailty or congestive heart failure GHSR, GHRHR, GIPR MEN1 2777/4885KMT2A 4788/4885ACHE 3514/4885
US-20020042415-A1 Dipeptide derivatives GIPR, GHRHR, GHSR MEN1 775/4885KMT2A 4848/4885ACHE 3808/4885
US-20010041703-A1 Dipeptide derivatives GIPR, GHRHR, GHSR MEN1 902/4885KMT2A 4832/4885ACHE 4103/4885
US-20020002165-A1 Dipeptide derivatives GIPR, GHRHR, GHSR MEN1 775/4885KMT2A 4848/4885ACHE 3808/4885
US-20040006063-A1 Dipeptide derivatives GIPR, GHRHR, GHSR MEN1 2231/4885KMT2A 4724/4885ACHE 3741/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.