Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX1 | P51575 | 1/20 | 0.47 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.45 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.45 |
| ▸ | FBP1 | P09467 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 2/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.39 |
| ▸ | CDK2 | P24941 | 2/20 | 0.39 |
| ▸ | CDK7 | P50613 | 2/20 | 0.39 |
| ▸ | CCNH | P51946 | 2/20 | 0.39 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | CCND1 | P24385 | 1/20 | 0.39 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5229776 | 0.88 | MEN1 (0.55) | FBP1MEN1KMT2AMAPTTP53 | |
| SCHEMBL5235859 | 0.86 | PLA2G1B (0.47) | P2RX1PLA2G1BATG4BMEN1KMT2A | |
| SCHEMBL5230476 | 0.81 | FBP1 (0.44) | FBP1CDK1CCNB1CCNA2CDK2 | |
| SCHEMBL5230424 | 0.79 | ALDH1A1 (0.49) | P2RX1PLA2G1BATG4BMEN1KMT2A | |
| SCHEMBL5233621 | 0.78 | SMN1; SMN2 (0.53) | P2RX1MEN1KMT2AMAPTPTGES2 | |
| SCHEMBL5228507 | 0.77 | HTT (0.58) | P2RX1PLA2G1BATG4BMEN1KMT2A | |
| SCHEMBL5231576 | 0.77 | MAPT (0.49) | FBP1MEN1KMT2ACDK1CCNB1 | |
| SCHEMBL5831691 | 0.77 | FBP1 (0.39) | FBP1MEN1KMT2AMCL1RAD51 | |
| SCHEMBL6615454 | 0.76 | MCL1 (0.38) | FBP1MCL1RAD51PTGES2ACLY | |
| SCHEMBL6617119 | 0.75 | CCR2 (0.41) | FBP1MEN1KMT2AMCL1RAD51 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1519932-B1 | BISARYLSULFONAMIDE COMPOUNDS AND THEIR USE IN CANCER THERAPY | CYCLACEL LTD (GB) | 2007-10-03 | — | — | EP | claimed |