Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.58 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.50 |
| ▸ | TYMS | P04818 | 1/20 | 0.48 |
| ▸ | AR | P10275 | 2/20 | 0.48 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.47 |
| ▸ | PGR | P06401 | 1/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.47 |
| ▸ | RORA | P35398 | 1/20 | 0.46 |
| ▸ | RORC | P51449 | 1/20 | 0.46 |
| ▸ | RORB | Q92753 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5229993 | 0.88 | PPARG (0.55) | MEN1KMT2ANR1H3TYMSAR | |
| SCHEMBL12334559 | 0.85 | HSD11B1 (0.64) | MEN1KMT2ANR1H3RORARORC | |
| SCHEMBL5230095 | 0.82 | PRMT1 (0.52) | MEN1KMT2ATYMSARPGR | |
| SCHEMBL2567685 | 0.81 | NR1H3 (0.71) | MEN1KMT2ANR1H3ARNR3C1 | |
| SCHEMBL5231919 | 0.77 | MEN1 (0.60) | MEN1KMT2ARORARORCRORB | |
| SCHEMBL5229467 | 0.77 | MEN1 (0.60) | MEN1KMT2ARORARORCRORB | |
| SCHEMBL29039874 | 0.75 | HSD11B1 (0.62) | MEN1KMT2AALDH1A1POLBMAPT | |
| SCHEMBL5232052 | 0.75 | TYMS (0.56) | MEN1KMT2ATYMSPGRALDH1A1 | |
| SCHEMBL7572845 | 0.75 | KMT2A (0.67) | MEN1KMT2ANR1H3ARCA1 | |
| SCHEMBL12334083 | 0.74 | MEN1 (1.00) | MEN1KMT2ARORARORCRORB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1519932-B1 | BISARYLSULFONAMIDE COMPOUNDS AND THEIR USE IN CANCER THERAPY | CYCLACEL LTD (GB) | 2007-10-03 | — | — | EP | claimed |