Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.72 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.72 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.72 |
| ▸ | RAB9A | P51151 | 4/20 | 0.71 |
| ▸ | NPC1 | O15118 | 2/20 | 0.71 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.69 |
| ▸ | HPGD | P15428 | 1/20 | 0.68 |
| ▸ | LMNA | P02545 | 4/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.66 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.63 |
| ▸ | RECQL | P46063 | 1/20 | 0.63 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.62 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.62 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1155517 | 0.93 | ALDH1A1 (0.72) | HDAC6HDAC2HDAC8RAB9ANPC1 | |
| SCHEMBL6077802 | 0.91 | L3MBTL1 (0.77) | HDAC6HDAC8CXCR4LMNAL3MBTL1 | |
| SCHEMBL11900090 | 0.91 | HDAC6 (0.85) | HDAC6HDAC2HDAC8RAB9AHPGD | |
| SCHEMBL10099566 | 0.88 | NR1H4 (0.69) | HDAC6CXCR4LMNAL3MBTL1HDAC1 | |
| SCHEMBL457082 | 0.87 | HDAC6 (0.79) | HDAC6HDAC2HDAC8RAB9AHPGD | |
| SCHEMBL15165753 | 0.85 | PPARG (0.64) | HDAC6HDAC2HDAC8CXCR4HPGD | |
| SCHEMBL4747957 | 0.85 | NR1H4 (0.81) | HDAC6HDAC2HDAC8RAB9AHPGD | |
| SCHEMBL6843720 | 0.85 | HDAC6 (0.77) | HDAC6HDAC2HDAC8RAB9AHPGD | |
| SCHEMBL29184442 | 0.85 | HDAC6 (0.76) | HDAC6HDAC2HDAC8RAB9AHPGD | |
| Hydrochloric Acid SCHEMBL3757721 | 0.85 | HDAC6 (0.76) | HDAC6HDAC2HDAC8RAB9AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1519932-B1 | BISARYLSULFONAMIDE COMPOUNDS AND THEIR USE IN CANCER THERAPY | CYCLACEL LTD (GB) | 2007-10-03 | — | — | EP | claimed |
| CN-112661584-B | Preparation method of photocatalytic N-alkyl amide compound | 大连理工大学 | 2022-08-05 | — | — | CN | disclosed |
| CN-112661584-A | Preparation method of photocatalytic N-alkyl amide compound | 大连理工大学 | 2021-04-16 | — | — | CN | disclosed |
| US-9840470-B2 | Targeting GLI proteins in human cancer by small molecules | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-12-12 | — | — | US | disclosed |
| CN-105016938-B | Method for preparing N-alkyl amide | 南京理工大学 | 2017-04-19 | — | — | CN | disclosed |
| CN-105820061-A | Method for synthesizing N-alkylamide | 南京理工大学 | 2016-08-03 | — | — | CN | disclosed |
| US-9370521-B2 | Targeting GLI proteins in human cancer by small molecules | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-06-21 | — | — | US | disclosed |
| US-9334230-B2 | Process of forming an amide | NANYANG TECHNOLOGICAL UNIVERSITY (SG) | 2016-05-10 | — | — | US | disclosed |
| US-20150361048-A1 | Targeting Gli Proteins in Human Cancer by Small Molecules | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2015-12-17 | — | — | US | disclosed |
| CN-105016938-A | Method for preparing N-alkenamides | UNIV NANJING SCIENCE & TECH | 2015-11-04 | — | — | CN | disclosed |
| CN-103113176-B | Method for synthesizing N-alkenamide | UNIV NANJING SCIENCE & TECH | 2015-06-17 | — | — | CN | disclosed |
| US-20140303160-A1 | Targeting GLI Proteins in Human Cancer by Small Molecules | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-10-09 | — | — | US | disclosed |
| CN-103113176-A | Method for synthesizing N-alkenamide | UNIV NANJING SCIENCE & TECH | 2013-05-22 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140303160-A1 | Targeting GLI Proteins in Human Cancer by Small Molecules | GLI2, GLI1, MYC | HDAC6 1244/4885HDAC2 2473/4885HDAC8 1569/4885 |
| US-20150361048-A1 | Targeting Gli Proteins in Human Cancer by Small Molecules | GLI2, GLI1, MYC | HDAC6 1244/4885HDAC2 2473/4885HDAC8 1569/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.