Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 12/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
| ▸ | CCR8 | P51685 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23389936 | 0.82 | CCR1 (0.40) | TGFBR1MAPK14CCR1CCR8THRB | |
| SCHEMBL29796504 | 0.82 | CCR1 (0.40) | TGFBR1MAPK14CCR1CCR8THRB | |
| SCHEMBL5229013 | 0.81 | TGFBR1 (0.42) | KDM4EMEN1USP2KMT2AL3MBTL1 | |
| SCHEMBL4874607 | 0.81 | TGFBR1 (0.52) | TGFBR1MAPK14THRB | |
| SCHEMBL4868073 | 0.80 | TGFBR1 (0.43) | TGFBR1MAPK14CCR1CCR8THRB | |
| SCHEMBL5232936 | 0.78 | PTGS2 (0.46) | TGFBR1MAPK14CCR1CCR8THRB | |
| SCHEMBL5232777 | 0.76 | TGFBR1 (0.46) | KDM4EMEN1KMT2AL3MBTL1TGFBR1 | |
| SCHEMBL5235703 | 0.73 | TGFBR1 (0.41) | TGFBR1MAPK14CCR1CCR8THRB | |
| SCHEMBL2189142 | 0.70 | KMT2A (0.62) | KDM4EMEN1KMT2AL3MBTL1ATM | |
| SCHEMBL4873701 | 0.69 | AKT1 (0.46) | MAPK1TGFBR1MAPK14CCR1CCR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1543001-B1 | PYRAZOLOPYRIDINE DERIVATIVES AS TGF BETA SIGNAL TRANSDUCTION INHIBITORS FOR THE TREATMENT OF CANCER | LILLY CO ELI (US) | 2007-08-15 | — | — | EP | disclosed |