Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRNP | P04156 | 2/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | IDE | P14735 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | SOS2 | Q07890 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4490632 | 0.86 | P2RX7 (0.39) | POLBKMT2AKDM4ELMNASMN1; SMN2 | |
| SCHEMBL6671176 | 0.86 | NPC1 (0.40) | POLBKMT2ASMN1; SMN2ACVR1CLK4 | |
| SCHEMBL5235795 | 0.84 | KDR (0.45) | LMNATGFBR1TLR8CYP1A2RET | |
| SCHEMBL5235225 | 0.84 | CYP1A2 (0.49) | SMN1; SMN2TGFBR1MAPK14CYP1A2PTGDR2 | |
| SCHEMBL29959459 | 0.84 | CYP1A2 (0.49) | SMN1; SMN2TGFBR1MAPK14CYP1A2PTGDR2 | |
| SCHEMBL5234890 | 0.83 | P2RX7 (0.39) | POLBKMT2AKDM4ESMN1; SMN2CYP1A2 | |
| SCHEMBL5238328 | 0.83 | THRB (0.44) | KMT2AKDM4ELMNASMN1; SMN2THRB | |
| SCHEMBL5236990 | 0.83 | GSK3A (0.44) | TGFBR1PTGDR2ABL1GSK3AGSK3B | |
| SCHEMBL5236574 | 0.83 | TSHR (0.48) | PRNPRXFP1POLBKMT2AKDM4E | |
| SCHEMBL5231308 | 0.81 | SRC (0.42) | TGFBR1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1543001-B1 | PYRAZOLOPYRIDINE DERIVATIVES AS TGF BETA SIGNAL TRANSDUCTION INHIBITORS FOR THE TREATMENT OF CANCER | LILLY CO ELI (US) | 2007-08-15 | — | — | EP | disclosed |
| EP-1397364-B1 | NOVEL PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | LILLY CO ELI (US) | 2007-07-25 | — | — | EP | disclosed |