Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | PRNP | P04156 | 2/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | CHKA | P35790 | 1/20 | 0.44 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.43 |
| ▸ | SOS2 | Q07890 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5231726 | 0.84 | GRM4 (0.44) | KDM4EKMT2AL3MBTL1GRM5GRM4 | |
| SCHEMBL4872056 | 0.83 | CYP1A2 (0.55) | KDM4EKMT2AL3MBTL1GRM4CYP1A2 | |
| SCHEMBL5231489 | 0.83 | PRNP (0.45) | PRNPRXFP1KDM4EKMT2APOLB | |
| SCHEMBL5233929 | 0.81 | CYP1A2 (0.50) | TSHRKMT2AL3MBTL1CYP1A2SMN1; SMN2 | |
| SCHEMBL5232920 | 0.81 | RAB9A (0.49) | KDM4EKMT2AL3MBTL1GRM5GRM4 | |
| SCHEMBL5231287 | 0.80 | NPC1 (0.49) | KDM4EKMT2APOLBL3MBTL1GRM4 | |
| SCHEMBL5233499 | 0.78 | GRM4 (0.43) | KDM4EKMT2AL3MBTL1GRM5GRM4 | |
| SCHEMBL5238508 | 0.77 | CYP1A2 (0.49) | KMT2ACYP1A2SMN1; SMN2 | |
| SCHEMBL5235583 | 0.75 | KDM5A (0.48) | TSHRKDM4EKMT2AL3MBTL1GRM5 | |
| SCHEMBL5239810 | 0.74 | THRB (0.40) | TSHRKDM4EKMT2ACHKAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397364-B1 | NOVEL PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | LILLY CO ELI (US) | 2007-07-25 | — | — | EP | disclosed |