Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 4/20 | 0.36 |
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.35 |
| ▸ | CHRM1 known ✓ | P11229 | 2/20 | 0.35 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.33 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | GAA | P10253 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | CASP1 | P29466 | 2/20 | 0.45 |
| ▸ | CASP7 | P55210 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL7164888 | 0.98 | MAPT (0.44) | MAPTKDM4EKMT2AGAAMEN1 | |
| SCHEMBL4667845 | 0.98 | MAPT (0.46) | MAPTKDM4EKMT2AGAAMEN1 | |
| Hydrochloric Acid SCHEMBL7171240 | 0.97 | MAPT (0.46) | MAPTKDM4EKMT2AGAAMEN1 | |
| Water SCHEMBL2921450 | 0.97 | MAPT (0.45) | MAPTKDM4EKMT2AGAAMEN1 | |
| Hydrochloric Acid SCHEMBL5566013 | 0.88 | GAA (0.61) | MAPTKDM4EKMT2AGAAMEN1 | |
| Hydrochloric Acid SCHEMBL7739871 | 0.86 | GAA (0.64) | MAPTKDM4EKMT2AGAAMEN1 | |
| SCHEMBL2930159 | 0.86 | GAA (0.63) | MAPTKDM4EKMT2AGAAMEN1 | |
| Hydrochloric Acid SCHEMBL15016532 | 0.84 | ALDH1A1 (0.47) | MAPTKDM4EKMT2AGAAMEN1 | |
| Hydrochloric Acid SCHEMBL15016563 | 0.84 | ALDH1A1 (0.47) | MAPTKDM4EKMT2AGAAMEN1 | |
| SCHEMBL15016505 | 0.83 | ALDH1A1 (0.46) | MAPTKDM4EKMT2AGAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1334713-B1 | Dyeing composition comprising diaminopyrazole and cationic compounds as oxidation bases and a coupling agent | OREAL (FR) | 2005-12-07 | — | — | EP | claimed |
| US-6905522-B2 | Dye composition comprising an oxidation base of the diaminopyrazole type, a cationic oxidation base and a coupler | L'OREAL S.A. (FR) | 2005-06-14 | — | — | US | claimed |
| US-20050097681-A9 | DYE COMPOSITION COMPRISING AN OXIDATION BASE OF THE DIAMINOPYRAZOLE TYPE, A CATIONIC OXIDATION BASE AND A COUPLER | L'OREAL S.A. (FR) | 2005-05-12 | — | — | US | claimed |
| US-20040045100-A1 | Dye composition comprising an oxidation base of the diaminopyrazole type, a cationic oxidation base and a coupler | KRAVTCHENKO SYLVAIN (FR) | 2004-03-11 | — | — | US | claimed |
| US-20070226917-A1 | Hair Dye Agent Comprising Organosilicon Copolymers with Amino Groups and Polyoxyalkylene Groups and Use Thereof | HENKEL KGAA (DE) | 2007-10-04 | — | — | US | disclosed |
| EP-1335696-B1 | ENZYMATIC COLOURING AGENTS | HENKEL KGAA (DE) | 2007-09-05 | — | — | EP | disclosed |
| EP-1744815-A1 | HAIR DYE AGENT COMPRISING ORGANOSILICON COPOLYMERS WITH AMINO GROUPS AND POLYOXYALKYLENE GROUPS AND USE THEREOF | Henkel Kommanditgesellschaft auf Aktien (DE) | 2007-01-24 | — | — | EP | disclosed |
| WO-2005102253-A1 | HAIR DYE AGENT COMPRISING ORGANOSILICON COPOLYMERS WITH AMINO GROUPS AND POLYOXYALKYLENE GROUPS AND USE THEREOF | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2005-11-03 | — | — | WO | disclosed |
| US-6905522-B2 | Dye composition comprising an oxidation base of the diaminopyrazole type, a cationic oxidation base and a coupler | L'OREAL S.A. (FR) | 2005-06-14 | — | — | US | disclosed |
| US-20050097681-A9 | DYE COMPOSITION COMPRISING AN OXIDATION BASE OF THE DIAMINOPYRAZOLE TYPE, A CATIONIC OXIDATION BASE AND A COUPLER | L'OREAL S.A. (FR) | 2005-05-12 | — | — | US | disclosed |
| US-20040045100-A1 | Dye composition comprising an oxidation base of the diaminopyrazole type, a cationic oxidation base and a coupler | KRAVTCHENKO SYLVAIN (FR) | 2004-03-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050097681-A9 | DYE COMPOSITION COMPRISING AN OXIDATION BASE OF THE DIAMINOPYRAZOLE TYPE, A CATIONIC OXIDATION BASE AND A COUPLER | KRT18, AOC1, CYB5R3 | ACHE 1629/4885CHRM2 2053/4885CHRM1 1603/4885 |
| US-20040045100-A1 | Dye composition comprising an oxidation base of the diaminopyrazole type, a cationic oxidation base and a coupler | KRT18, AOC1, CYB5R3 | ACHE 1629/4885CHRM2 2053/4885CHRM1 1603/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.