Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PANK3 | Q9H999 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 2/20 | 0.43 |
| ▸ | ACHE | P22303 | 2/20 | 0.43 |
| ▸ | BACE1 | P56817 | 2/20 | 0.43 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.43 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.43 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.43 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | MGLL | Q99685 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | HRH2 | P25021 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5232866 | 0.95 | PANK3 (0.47) | KDM4EPANK3BCHEACHEBACE1 | |
| SCHEMBL5234185 | 0.85 | KDM4E (0.59) | KDM4EPOLBPKMMGLLSMN1; SMN2 | |
| SCHEMBL5238882 | 0.85 | EGLN1 (0.51) | KDM4EPOLBPKMCACNA1HMGLL | |
| SCHEMBL593717 | 0.82 | SMN1; SMN2 (0.48) | KDM4EPOLBPANK3PKMBCHE | |
| SCHEMBL5237235 | 0.81 | MGLL (0.53) | KDM4EPOLBPANK3MGLLSLC6A7 | |
| SCHEMBL31589961 | 0.80 | EGLN1 (0.55) | KDM4EPKMMGLLSMN1; SMN2HPGD | |
| SCHEMBL5232948 | 0.80 | MGLL (0.60) | KDM4EPOLBPKMMGLLSMN1; SMN2 | |
| SCHEMBL5237745 | 0.78 | MGLL (0.60) | KDM4EPOLBPKMMGLLSMN1; SMN2 | |
| SCHEMBL5238137 | 0.78 | KCNA5 (0.58) | POLBSLC6A7EPHX2HRH2HRH1 | |
| SCHEMBL31589397 | 0.78 | HTR1A (0.52) | KDM4EPKMMGLLSLC6A7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701946-B1 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI AVENTIS (FR) | 2007-12-19 | — | — | EP | claimed |
| EP-1701946-B1 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI AVENTIS (FR) | 2007-12-19 | — | — | EP | disclosed |
| EP-1701946-A2 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | Sanofi-Aventis (FR) | 2006-09-20 | — | — | EP | disclosed |
| WO-2005070910-A2 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI-AVENTIS (FR) | 2005-08-04 | — | — | WO | disclosed |