Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 6/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5236702 | 0.88 | FAAH (0.57) | FAAHMAPTMAPK1HTTSMN1; SMN2 | |
| SCHEMBL5233485 | 0.87 | NPSR1 (0.50) | FAAHMAPTMAPK1HTTSMN1; SMN2 | |
| SCHEMBL5232354 | 0.87 | FAAH (0.61) | FAAHMAPTMAPK1HTTSMN1; SMN2 | |
| SCHEMBL5232412 | 0.86 | FAAH (0.46) | FAAHSMN1; SMN2HPGDTSHRMEN1 | |
| SCHEMBL5236215 | 0.84 | FAAH (0.43) | FAAHMAPTSMN1; SMN2HPGDNPSR1 | |
| SCHEMBL5237873 | 0.81 | ALDH1A1 (0.58) | FAAHMAPTMAPK1HTTSMN1; SMN2 | |
| SCHEMBL5236929 | 0.81 | MAPT (0.73) | FAAHMAPTMAPK1HTTSMN1; SMN2 | |
| SCHEMBL5232196 | 0.81 | MAPT (0.58) | FAAHMAPTMAPK1HTTSMN1; SMN2 | |
| SCHEMBL5233512 | 0.80 | MAPT (0.51) | MAPTMAPK1SMN1; SMN2LMNAHPGD | |
| SCHEMBL5235029 | 0.79 | GAA (0.52) | FAAHMAPTMAPK1HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701946-B1 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI AVENTIS (FR) | 2007-12-19 | — | — | EP | claimed |