Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | LMNA | P02545 | 6/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HRH2 | P25021 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5232354 | 0.96 | FAAH (0.61) | FAAHMAPTLMNAKDM4EGAA | |
| SCHEMBL5233512 | 0.89 | MAPT (0.51) | MAPTLMNAKDM4EGAAMAPK1 | |
| SCHEMBL5235029 | 0.88 | GAA (0.52) | FAAHMAPTLMNAKDM4EGAA | |
| SCHEMBL5233753 | 0.88 | FAAH (0.48) | FAAHMAPTLMNAKDM4EGAA | |
| SCHEMBL5239244 | 0.88 | ALDH1A1 (0.52) | MAPTLMNAKDM4EGAAHTT | |
| SCHEMBL5233485 | 0.85 | NPSR1 (0.50) | FAAHMAPTLMNAGAAHTT | |
| SCHEMBL5239162 | 0.85 | MAPT (0.53) | MAPTLMNAKDM4EGAAHTT | |
| SCHEMBL5238043 | 0.85 | CA12 (0.50) | FAAHMAPTLMNAKDM4EGAA | |
| SCHEMBL5235359 | 0.85 | MAPT (0.58) | FAAHMAPTLMNAKDM4EGAA | |
| SCHEMBL5236694 | 0.84 | FAAH (0.52) | FAAHMAPTLMNAGAAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701946-B1 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI AVENTIS (FR) | 2007-12-19 | — | — | EP | claimed |