SCHEMBL5232196

SCHEMBL5232196

CNC(=O)COC(=O)N1CCN(c2ccc(F)c(Cl)c2)CC1

nearest known ligand 0.58

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MAPT P10636 6/20 0.58
HTT P42858 2/20 0.58
MAPK1 P28482 1/20 0.58
SMN1; SMN2 Q16637 2/20 0.54
FAAH O00519 1/20 0.49
RAB9A P51151 1/20 0.47
MMP2 P08253 1/20 0.47
ADAMTS5 Q9UNA0 1/20 0.47
MEN1 O00255 1/20 0.45
KMT2A Q03164 1/20 0.45
CA1 P00915 1/20 0.45
CA2 P00918 1/20 0.45
CA4 P22748 1/20 0.45
CA9 Q16790 1/20 0.45
PHGDH O43175 1/20 0.44
KDM4E B2RXH2 1/20 0.44
LMNA P02545 1/20 0.44
GAA P10253 1/20 0.44
TP53 P04637 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5236929 0.90 MAPT (0.73) MAPTHTTMAPK1SMN1; SMN2FAAH
SCHEMBL5232354 0.86 FAAH (0.61) MAPTHTTMAPK1SMN1; SMN2FAAH
SCHEMBL5237873 0.85 ALDH1A1 (0.58) MAPTHTTMAPK1SMN1; SMN2FAAH
SCHEMBL5238704 0.84 MAPT (0.55) MAPTHTTMAPK1SMN1; SMN2FAAH
SCHEMBL5233900 0.83 ALDH1A1 (0.55) MAPTHTTMAPK1SMN1; SMN2MEN1
SCHEMBL5236702 0.82 FAAH (0.57) MAPTHTTMAPK1SMN1; SMN2FAAH
SCHEMBL5236667 0.81 LMNA (0.55) MAPTHTTMAPK1SMN1; SMN2FAAH
SCHEMBL5233993 0.81 MAPT (0.53) MAPTHTTMAPK1SMN1; SMN2FAAH
SCHEMBL5233753 0.81 FAAH (0.48) MAPTHTTMAPK1SMN1; SMN2FAAH
SCHEMBL5239244 0.80 ALDH1A1 (0.52) MAPTHTTMAPK1SMN1; SMN2MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1701946-B1 DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME SANOFI AVENTIS (FR) 2007-12-19 EP claimed