Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29666271 | 1.00 | HTR2A (0.31) | HTR2ANOTUM | |
| SCHEMBL24124845 | 0.80 | — | — | |
| SCHEMBL29360641 | 0.79 | SIGMAR1 (0.37) | — | |
| SCHEMBL14817223 | 0.75 | — | — | |
| SCHEMBL30024117 | 0.75 | — | — | |
| SCHEMBL29516288 | 0.75 | — | — | |
| Hydrochloric Acid SCHEMBL29791533 | 0.73 | — | — | |
| SCHEMBL30271241 | 0.73 | KDM4E (0.32) | — | |
| SCHEMBL30090202 | 0.72 | ADORA3 (0.31) | — | |
| SCHEMBL30498729 | 0.72 | NOTUM (0.33) | NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110087466-A | ACTIVE COMPOUND COMBINATIONS | 拜耳作物科学股份公司 | 2019-08-02 | — | — | CN | claimed |
| CN-105025899-B | Having a2AHeterobicyclically substituted- [1,2,4 ] antagonists]Triazolo [1,5-c]Quinazoline-5-amine compounds | 默沙东公司 | 2017-08-18 | — | — | CN | claimed |
| US-10906886-B2 | Substituted 5,6,7,8-tetrahydroimidazo[1,5-a]pyrazines as factor xia inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-02-02 | — | — | US | disclosed |
| US-20180265494-A1 | SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUNDS AS FACTOR XIA INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2018-09-20 | — | — | US | disclosed |
| EP-2899183-B1 | Substituted Tetrahydroisoquinoline Compounds as Factor Xia Inhibitors | BRISTOL MYERS SQUIBB CO (US) | 2018-09-19 | — | — | EP | disclosed |
| US-10000466-B2 | Substituted 4,5,6,7-tetrahydropyrazolo[3,4-c]pyridines as factor XIa inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-06-19 | — | — | US | disclosed |
| CN-107849014-A | A kind of biphenyl derivatives and preparation method thereof and purposes in medicine | 四川海思科制药有限公司 | 2018-03-27 | — | — | CN | disclosed |
| US-20170305880-A1 | SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUNDS AS FACTOR XIA INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2017-10-26 | — | — | US | disclosed |
| CN-105025899-B | Having a2AHeterobicyclically substituted- [1,2,4 ] antagonists]Triazolo [1,5-c]Quinazoline-5-amine compounds | 默沙东公司 | 2017-08-18 | — | — | CN | disclosed |
| US-9725435-B2 | Substituted 4,5,6,7-tetrahydropyrazolo[4,3-c]pyridines as factor XIa inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-08-08 | — | — | US | disclosed |
| EP-1896420-B1 | PROCESS OF PRODUCING BLEACH BOOSTERS | BASF SE (DE) | 2017-01-18 | — | — | EP | disclosed |
| EP-1206515-B1 | FORMULATION COMPONENTS RESISTANT TOWARDS DECOMPOSITION BY AROMATIZATION, COMPOSITIONS AND LAUNDRY METHODS EMPLOYING SAME | PROCTER & GAMBLE (US) | 2006-04-12 | — | — | EP | disclosed |
| CN-1639162-A | Pyrido(2,1-a)isoquinoline derivatives as DPP-IV inhibitors | HOFFMANN LA ROCHE (CH) | 2005-07-13 | — | — | CN | disclosed |
| US-20050113246-A1 | Process of producing an organic catalyst | THE PROCTER & GAMBLE COMPANY | 2005-05-26 | — | — | US | disclosed |
| WO-2005047264-A1 | PROCESS FOR PRODUCING DIHYDROISOQUINOLINE ZWITTERIONS | THE PROCTER & GAMBLE COMPANY (US) | 2005-05-26 | — | — | WO | disclosed |
| EP-1206515-A1 | FORMULATION COMPONENTS RESISTANT TOWARDS DECOMPOSITION BY AROMATIZATION, COMPOSITIONS AND LAUNDRY METHODS EMPLOYING SAME | The Procter & Gamble Company (US) | 2002-05-22 | — | — | EP | disclosed |
| US-6358974-B1 | USED AS AS MODULATORS OF DOPAMINE D.SUB.3 RECEPTORS, IN THERAPY AS ANTIPSYCHOTIC AGENTS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-03-19 | — | — | US | disclosed |
| EP-1137638-A2 | ISOQUINOLINE DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 2001-10-04 | — | — | EP | disclosed |
| WO-2001016273-A1 | FORMULATION COMPONENTS RESISTANT TOWARDS DECOMPOSITION BY AROMATIZATION, COMPOSITIONS AND LAUNDRY METHODS EMPLOYING SAME | THE PROCTER & GAMBLE COMPANY (US) | 2001-03-08 | — | — | WO | disclosed |
| WO-2000024717-A2 | ISOQUINOLINE DERIVATIVES | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-05-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10000466-B2 | Substituted 4,5,6,7-tetrahydropyrazolo[3,4-c]pyridines as factor XIa inhibitors | F12, TFPI, F11 | HTR2A 2907/4885NOTUM 1548/4885 |
| US-20170305880-A1 | SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUNDS AS FACTOR XIA INHIBITORS | TFPI, TFPI2, KLKB1 | HTR2A 1482/4885NOTUM 781/4885 |
| US-10906886-B2 | Substituted 5,6,7,8-tetrahydroimidazo[1,5-a]pyrazines as factor xia inhibitors | TFPI, F12, F11 | HTR2A 1194/4885NOTUM 559/4885 |
| US-20180265494-A1 | SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUNDS AS FACTOR XIA INHIBITORS | TFPI, TFPI2, KLKB1 | HTR2A 1482/4885NOTUM 781/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.