Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | SLC26A6 | Q9BXS9 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | PDE1A | P54750 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5237790 | 0.91 | SLC26A6 (0.41) | BRD4SLC26A6KIF11SMN1; SMN2MAPT | |
| SCHEMBL4059248 | 0.90 | SLC26A6 (0.43) | BRD4SLC26A6KIF11SMN1; SMN2MAPT | |
| SCHEMBL6208130 | 0.88 | KIF11 (0.48) | BRD4SLC26A6KIF11SMN1; SMN2MAPT | |
| SCHEMBL3958081 | 0.81 | KIF11 (0.55) | KIF11 | |
| SCHEMBL4058305 | 0.81 | KIF11 (0.44) | BRD4SLC26A6KIF11MAPTTHRB | |
| SCHEMBL4060901 | 0.79 | KIF11 (0.42) | BRD4SLC26A6KIF11MAPTTHRB | |
| SCHEMBL5233038 | 0.78 | SLC26A6 (0.39) | BRD4SLC26A6KIF11SMN1; SMN2MAPT | |
| SCHEMBL6208219 | 0.78 | SMN1; SMN2 (0.45) | BRD4SLC26A6KIF11SMN1; SMN2MAPT | |
| SCHEMBL4043063 | 0.78 | SMN1; SMN2 (0.44) | SLC26A6KIF11SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL3901729 | 0.78 | SMN1; SMN2 (0.48) | SLC26A6KIF11SMN1; SMN2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781673-A1 | SELECTED FUSED HETEROCYCLICS AND USES THEREOF | AstraZeneca AB (SE) | 2007-05-09 | — | — | EP | disclosed |
| WO-2006018627-A1 | SELECTED FUSED HETEROCYCLICS AND USES THEREOF | ASTRAZENECA AB (SE) | 2006-02-23 | — | — | WO | disclosed |