SCHEMBL523446

SCHEMBL523446

N#Cc1ccc(Oc2ccccc2)cc1C#N

nearest known ligand 0.68

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.65
HPGD P15428 2/20 0.65
CYP19A1 P11511 2/20 0.65
MAOB P27338 3/20 0.59
NPSR1 Q6W5P4 1/20 0.56
MAOA P21397 2/20 0.51
AR P10275 8/20 0.49
LTA4H P09960 1/20 0.48
TSHR P16473 1/20 0.48
PDE4B Q07343 1/20 0.48
MEN1 O00255 1/20 0.46
KMT2A Q03164 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9745473 1.00 ALDH1A1 (0.65) ALDH1A1HPGDCYP19A1MAOBNPSR1
SCHEMBL9747026 1.00 ALDH1A1 (0.65) ALDH1A1HPGDCYP19A1MAOBNPSR1
SCHEMBL9745656 0.96 ALDH1A1 (0.61) ALDH1A1HPGDCYP19A1MAOBNPSR1
SCHEMBL9746267 0.96 ALDH1A1 (0.61) ALDH1A1HPGDCYP19A1MAOBNPSR1
SCHEMBL9746946 0.96 ALDH1A1 (0.61) ALDH1A1HPGDCYP19A1MAOBNPSR1
SCHEMBL5143806 0.96 ALDH1A1 (0.61) ALDH1A1HPGDCYP19A1MAOBNPSR1
SCHEMBL9747762 0.96 ALDH1A1 (0.61) ALDH1A1HPGDCYP19A1MAOBNPSR1
SCHEMBL28487747 0.92 ALDH1A1 (0.57) ALDH1A1HPGDCYP19A1MAOBNPSR1
SCHEMBL13908822 0.92 CYP19A1 (0.65) ALDH1A1HPGDCYP19A1MAOBNPSR1
SCHEMBL1377229 0.92 CYP19A1 (0.62) ALDH1A1HPGDCYP19A1MAOBNPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 140 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3965738-B1 METHOD FOR PRODUCTION OF LIPOSOMES UNIV DO MINHO (PT) 2025-08-06 EP disclosed
EP-3877447-B1 COMPOSITION OF PHTHALONITRILE RESIN MATRIX FOR POLYMER COMPOSITE MATERIALS, METHOD FOR FABRICATION THEREOF, METHOD FOR MANUFACTURING OF POLYMER COMPOSITE MATERIAL, AND MATERIAL OBTAINED BY THIS METHOD JOINT STOCK COMPANY (RU) 2024-07-17 EP disclosed
CN-117736232-A Green synthesis method of high-yield alpha (beta) -tetra-substituent-dihydroxyl silicon phthalocyanine derivative 浙江工业大学 2024-03-22 CN disclosed
US-20240018109-A1 METHOD FOR SYNTHESIS OF ROXADUSTAT AND INTERMEDIATE THEREOF, AND INTERMEDIATE THEREOF JUMPCAN (SHANGHAI) MEDICAL TECHNOLOGY CO., LTD (CN) 2024-01-18 US disclosed
US-20240018109-A1 METHOD FOR SYNTHESIS OF ROXADUSTAT AND INTERMEDIATE THEREOF, AND INTERMEDIATE THEREOF JUMPCAN (SHANGHAI) MEDICAL TECHNOLOGY CO., LTD (CN) 2024-01-18 US disclosed
EP-3705541-B1 THREE-DIMENSIONAL PRINTING INK COMPRISING PHTHALONITRILE OLIGOMER LG CHEMICAL LTD (KR) 2023-09-06 EP disclosed
US-20230183180-A1 PROCESS OF MAKING ROXADUSTAT SUZHOU PENGXU PHARMATECH CO., LTD. (CN) 2023-06-15 US disclosed
US-11674045-B2 Three-dimensional printing ink comprising a phthalonitrile oligomer LG CHEM, LTD (KR) 2023-06-13 US disclosed
US-11674045-B2 Three-dimensional printing ink comprising a phthalonitrile oligomer LG CHEM, LTD (KR) 2023-06-13 US disclosed
CN-110461814-B Resin blends, prepregs and articles containing a phthalonitrile reactive diluent and a bisphthalonitrile resin 3M创新有限公司 2023-04-14 CN disclosed
US-5149800-A For natural or synthetic resins, especially polyolefins and polyurethane foams MILLIKEN RESEARCH CORPORATION (US) 1992-09-22 US disclosed
US-5135717-A Imaging therapy BRITISH TECHNOLOGY GROUP USA INC. (US) 1992-08-04 US disclosed
US-5135972-A For polymeric substrates MILLIKEN RESEARCH CORPORATION (US) 1992-08-04 US disclosed
EP-0484027-A1 Polysubstituted phthalocyanines ZENECA LIMITED (GB) 1992-05-06 EP disclosed
EP-0434727-A1 RED-SHIFTED PHTHALOCYANINE AND TETRABENZTRIAZAPORPHYRIN REAGENTS BRITISH TECHNOLOGY GROUP (USA) INCORPORATED (US) 1991-07-03 EP disclosed
EP-0398620-A2 Poly(oxyalkylene) modified phthalocyanine colorants MILLIKEN RESEARCH CORPORATION (US) 1990-11-22 EP disclosed
WO-1990002747-A1 RED-SHIFTED PHTHALOCYANINE AND TETRABENZTRIAZAPORPHYRIN REAGENTS ULTRA DIAGNOSTICS CORPORATION (US) 1990-03-22 WO disclosed
US-4587325-A N-HETEROCYCLE POLYMERS THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) 1986-05-06 US disclosed
US-4145264-A AROMATIC O-DICARBOXYLIC ACID NITRILES ELECTROLYZED IN AN ORGANIC LIQUID WITH AN ALKALINE ACTIVATOR BASF AKTIENGESELLSCHAFT (DE) 1979-03-20 US disclosed
US-3994921-A COLORING PLASTICS AND LACQUERS YELLOW CIBA-GEIGY CORPORATION (US) 1976-11-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230183180-A1 PROCESS OF MAKING ROXADUSTAT CYP2B6, UGT1A6, CYP2D6 ALDH1A1 752/4885HPGD 298/4885CYP19A1 77/4885
US-20240018109-A1 METHOD FOR SYNTHESIS OF ROXADUSTAT AND INTERMEDIATE THEREOF, AND INTERMEDIATE THEREOF SRM, SMS, SMOX ALDH1A1 101/4885HPGD 642/4885CYP19A1 121/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.