Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 2/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.42 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.42 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CHUK | O15111 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | SIK1 | P57059 | 1/20 | 0.33 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.33 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5237466 | 0.86 | PDK1 (0.38) | PDK1PDK2PDK3PDK4KMT2A | |
| SCHEMBL4610178 | 0.84 | PDK1 (0.62) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL21875055 | 0.80 | KMT2A (0.45) | KMT2AHTTL3MBTL1MAPTCYP1A2 | |
| SCHEMBL3715260 | 0.79 | ALDH1A1 (0.52) | PDK1PDK2PDK3PDK4KMT2A | |
| SCHEMBL613613 | 0.76 | MAPT (0.58) | KMT2AHTTMAPTCYP1A2CYP2C19 | |
| SCHEMBL25095439 | 0.73 | PDK1 (0.55) | PDK1PDK2PDK3PDK4KMT2A | |
| SCHEMBL3040193 | 0.72 | KMT2A (0.38) | KMT2AMAPTCYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL8389121 | 0.70 | ANO1 (0.40) | L3MBTL1MAPTCA2ANO1 | |
| SCHEMBL10855357 | 0.70 | DRD2 (0.41) | KMT2AHTTMAPTCYP1A2ALDH1A1 | |
| SCHEMBL26575330 | 0.69 | ALDH1A1 (0.55) | KMT2AHTTL3MBTL1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1664058-B1 | SUBSTITUTED THIENOIMIDAZOLES, METHOD FOR PRODUCTION AND USE THEREOF AS MEDICAMENT OR DIAGNOSTIC AND MEDICAMENTS COMPRISING THE SAME | SANOFI AVENTIS DEUTSCHLAND (DE) | 2007-11-14 | — | — | EP | disclosed |
| US-7179830-B2 | Substituted thienoimidazoles useful for disease treatment and prevention | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-02-20 | — | — | US | disclosed |
| EP-1664058-A1 | SUBSTITUTED THIENOIMIDAZOLES, METHOD FOR PRODUCTION AND USE THEREOF AS MEDICAMENT OR DIAGNOSTIC AND MEDICAMENTS COMPRISING THE SAME | Sanofi-Aventis Deutschland GmbH (DE) | 2006-06-07 | — | — | EP | disclosed |
| US-20050075385-A1 | Substituted thienoimidazoles useful for disease treatment and prevention | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2005-04-07 | — | — | US | disclosed |
| WO-2005026173-A1 | SUBSTITUTED THIENOIMIDAZOLES, METHOD FOR PRODUCTION AND USE THEREOF AS MEDICAMENT OR DIAGNOSTIC AND MEDICAMENTS COMPRISING THE SAME | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2005-03-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050075385-A1 | Substituted thienoimidazoles useful for disease treatment and prevention | TPMT, TYMS, SLC19A2 | PDK1 1767/4885PDK2 981/4885PDK3 1824/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.