Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.50 |
| ▸ | HTR1D | P28221 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | SFN | P31947 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTR1B | P28222 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5523413 | 0.85 | KMT2A (0.57) | MAPTKMT2AL3MBTL1TSHRTP53 | |
| SCHEMBL692136 | 0.84 | KMT2A (0.65) | MRGPRX4HTR1DMAPTKMT2AALDH1A1 | |
| SCHEMBL9722695 | 0.84 | MRGPRX4 (0.51) | MRGPRX4HTR1DMAPTKMT2AALDH1A1 | |
| SCHEMBL8816518 | 0.83 | LMNA (0.58) | MRGPRX4HTR1DMAPTKMT2AALDH1A1 | |
| Alcohol SCHEMBL28150988 | 0.83 | KMT2A (0.59) | MRGPRX4HTR1DMAPTKMT2AALDH1A1 | |
| Ammonia Solution, Strong SCHEMBL27869911 | 0.82 | KMT2A (0.62) | MRGPRX4HTR1DMAPTKMT2AALDH1A1 | |
| SCHEMBL9195201 | 0.82 | HTT (0.53) | MRGPRX4HTR1DMAPTKMT2AALDH1A1 | |
| Water SCHEMBL28856010 | 0.82 | KMT2A (0.62) | MRGPRX4HTR1DMAPTKMT2AALDH1A1 | |
| SCHEMBL27372722 | 0.82 | KMT2A (0.62) | MRGPRX4HTR1DMAPTKMT2AALDH1A1 | |
| SCHEMBL6203335 | 0.82 | HTT (0.53) | MRGPRX4HTR1DMAPTKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8309543-B2 | Compositions useful as inhibitors of voltage-gated sodium channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-11-13 | — | — | US | disclosed |
| US-20120238578-A1 | COMPOSITIONS USEFUL AS INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-09-20 | — | — | US | disclosed |
| EP-1786782-A2 | BISARYL-SULFONAMIDES | Amgen Inc. (US) | 2007-05-23 | — | — | EP | disclosed |
| WO-2006020830-A2 | BISARYL-SULFONAMIDES | AMGEN INC. (US) | 2006-02-23 | — | — | WO | disclosed |
| US-20050222448-A1 | N-sulphonylaminoacetonitriles having pesticidal properties | STEIGER ARTHUR | 2005-10-06 | — | — | US | disclosed |
| EP-1517887-A1 | N-SULPHONYLAMINOACETONITRILES HAVING PESTICIDAL PROPERTIES | Novartis AG (CH) | 2005-03-30 | — | — | EP | disclosed |
| WO-2004000798-A1 | N-SULPHONYLAMINOACETONITRILES HAVING PESTICIDAL PROPERTIES | NOVARTIS AG (CH) | 2003-12-31 | — | — | WO | disclosed |
| WO-2002050052-A1 | N-ACYL AMINOACETONITRILES HAVING PESTICIDAL PROPERTIES | SYNGENTA PARTICIPATIONS AG (CH) | 2002-06-27 | — | — | WO | disclosed |
| EP-0586393-A1 | SUBSTITUTED-2-PHENYL-3-METHOXYPROPENOATES AS FUNGICIDES | ZENECA LIMITED (GB) | 1994-03-16 | — | — | EP | disclosed |
| WO-1992018487-A1 | SUBSTITUTED-2-PHENYL-3-METHOXYPROPENOATES AS FUNGICIDES | ZENECA LIMITED (GB) | 1992-10-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120238578-A1 | COMPOSITIONS USEFUL AS INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | SCNN1G, KCNN3, KCNN2 | MRGPRX4 1461/4885HTR1D 2367/4885MAPT 1883/4885 |
| US-20050222448-A1 | N-sulphonylaminoacetonitriles having pesticidal properties | DDT, ACHE, NIT2 | MRGPRX4 4059/4885HTR1D 3570/4885MAPT 3083/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.