Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | BCL2 | P10415 | 1/20 | 0.37 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5236387 | 0.97 | KDM4E (0.39) | KDM4ELMNAALDH1A1MEN1ALOX15 | |
| SCHEMBL5228396 | 0.90 | KMT2A (0.34) | KDM4EALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL5230595 | 0.89 | KDM4E (0.43) | KDM4ELMNAALDH1A1MEN1ALOX15 | |
| SCHEMBL5230600 | 0.89 | KDM4E (0.43) | KDM4ELMNAALDH1A1MEN1ALOX15 | |
| SCHEMBL5234466 | 0.89 | APP (0.36) | LMNAALDH1A1MEN1KMT2AGAA | |
| SCHEMBL5233446 | 0.88 | NPC1 (0.35) | KDM4EALDH1A1MEN1ALOX15KMT2A | |
| SCHEMBL5234172 | 0.88 | NOTUM (0.38) | KDM4ELMNAALDH1A1MEN1ALOX15 | |
| SCHEMBL5238208 | 0.87 | ALDH1A1 (0.38) | KDM4ELMNAALDH1A1ALOX15RAB9A | |
| SCHEMBL5234129 | 0.87 | ADORA3 (0.37) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5236797 | 0.86 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730116-B1 | 4-CARBOX PYRAZOLE DERIVATES USEFUL AS ANTI-VIRAL AGENTS | SMITHKLINE BEECHAM CORP (US) | 2007-09-05 | — | — | EP | claimed |