Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.37 |
| ▸ | SORD | Q00796 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5237292 | 0.87 | KDM4E (0.43) | KDM4ETP53HRH3RXFP1THRB | |
| SCHEMBL5237938 | 0.81 | PANK3 (0.41) | MAPTHRH3HTR1AHTR2A | |
| SCHEMBL5236318 | 0.80 | KDM4E (0.38) | KDM4ELMNATP53MAPTHRH3 | |
| SCHEMBL5237297 | 0.72 | KDM4E (0.40) | KDM4ELMNATP53MAPTHRH3 | |
| SCHEMBL5235191 | 0.71 | ALDH1A1 (0.47) | KDM4EMAPTTHRBPOLBALDH1A1 | |
| SCHEMBL5233805 | 0.70 | PANK3 (0.39) | HRH3 | |
| SCHEMBL14224744 | 0.68 | CKS1B (0.53) | KDM4ELMNATP53MAPTHRH3 | |
| SCHEMBL3710705 | 0.66 | SLC6A7 (0.62) | KDM4ELMNAHRH3RXFP1SLC6A7 | |
| SCHEMBL13073553 | 0.65 | SLC6A7 (0.57) | KDM4ELMNAHRH3RXFP1SLC6A7 | |
| SCHEMBL26945270 | 0.65 | KDM4E (0.43) | KDM4ELMNATP53MAPTRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701946-B1 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI AVENTIS (FR) | 2007-12-19 | — | — | EP | claimed |