Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | SORD | Q00796 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5236309 | 0.87 | KDM4E (0.40) | KDM4ERXFP1SLC6A7HRH3GRM1 | |
| SCHEMBL5235191 | 0.83 | ALDH1A1 (0.47) | KDM4EALDH1A1THRB | |
| SCHEMBL5237297 | 0.77 | KDM4E (0.40) | KDM4ERXFP1SLC6A7HRH3GRM1 | |
| SCHEMBL5236755 | 0.76 | MGLL (0.41) | SMN1; SMN2 | |
| SCHEMBL5238186 | 0.75 | CYP2C19 (0.43) | ALDH1A1 | |
| SCHEMBL5238153 | 0.74 | KDM4E (0.49) | KDM4EHRH3ALDH1A1SMN1; SMN2SORD | |
| SCHEMBL5238349 | 0.73 | MAPT (0.45) | KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL5233791 | 0.73 | PANK3 (0.41) | KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL5239779 | 0.73 | MAPT (0.40) | KDM4EALDH1A1SMN1; SMN2TP53L3MBTL1 | |
| SCHEMBL5239092 | 0.72 | MEN1 (0.41) | KDM4EALDH1A1SMN1; SMN2L3MBTL1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701946-B1 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI AVENTIS (FR) | 2007-12-19 | — | — | EP | claimed |