Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CKS1B | P61024 | 1/20 | 0.53 |
| ▸ | SKP1 | P63208 | 1/20 | 0.53 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.53 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.51 |
| ▸ | DPP4 | P27487 | 1/20 | 0.49 |
| ▸ | SORD | Q00796 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14768692 | 0.88 | SLC6A7 (0.51) | SLC6A7KDM4EHRH3DPP4SORD | |
| SCHEMBL14411664 | 0.86 | SLC6A7 (0.54) | SLC6A7KDM4EHRH3DPP4SORD | |
| SCHEMBL22481434 | 0.85 | SLC6A7 (0.53) | CKS1BSKP1SKP2SLC6A7KDM4E | |
| SCHEMBL11090165 | 0.84 | GNAI3 (0.49) | SLC6A7KDM4EHRH3DPP4MEN1 | |
| SCHEMBL13073553 | 0.83 | SLC6A7 (0.57) | CKS1BSKP1SKP2SLC6A7KDM4E | |
| SCHEMBL27723124 | 0.82 | SLC6A7 (0.59) | SLC6A7KDM4EHRH3SORDMEN1 | |
| SCHEMBL3710705 | 0.81 | SLC6A7 (0.62) | SLC6A7KDM4EHRH3SORDMEN1 | |
| SCHEMBL11080229 | 0.80 | KDM4E (0.59) | CKS1BSKP1SKP2SLC6A7KDM4E | |
| SCHEMBL11079223 | 0.80 | KDM4E (0.72) | SLC6A7KDM4EMEN1KMT2APOLB | |
| SCHEMBL18701806 | 0.79 | GPR119 (0.54) | CKS1BSKP1SKP2SLC6A7KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7354919-B2 | Isoxazole compositions useful as inhibitors of ERK | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-04-08 | — | — | US | disclosed |