Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | PHGDH | O43175 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5235799 | 0.90 | MAPT (0.47) | MAPTALDH1A1SMN1; SMN2KDM4ELMNA | |
| SCHEMBL5239092 | 0.86 | MEN1 (0.41) | ADAMTS5MAPTALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL5236739 | 0.85 | HTR1A (0.44) | MAPTALDH1A1SMN1; SMN2KDM4EHTT | |
| SCHEMBL5231416 | 0.84 | NOTUM (0.49) | PHGDHMAPTSMN1; SMN2LMNATP53 | |
| SCHEMBL5232288 | 0.83 | MAPT (0.41) | MAPTALDH1A1SMN1; SMN2KDM4ELMNA | |
| SCHEMBL5235440 | 0.83 | ALDH1A1 (0.40) | ADAMTS5MAPTALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL5232234 | 0.82 | USP2 (0.38) | ADAMTS5MMP2SCN9AMAPTALDH1A1 | |
| SCHEMBL5239862 | 0.81 | SRD5A2 (0.39) | MAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL5234836 | 0.81 | MEN1 (0.43) | MAPTALDH1A1SMN1; SMN2KDM4ELMNA | |
| SCHEMBL5239779 | 0.80 | MAPT (0.40) | MMP2MMP13MAPTALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701946-B1 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI AVENTIS (FR) | 2007-12-19 | — | — | EP | claimed |