Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | DRD2 | P14416 | 3/20 | 0.40 |
| ▸ | DRD4 | P21917 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 5/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MMP14 | P50281 | 1/20 | 0.39 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | CCR1 | P32246 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5235440 | 0.96 | ALDH1A1 (0.40) | MEN1KMT2ALMNAALDH1A1DRD2 | |
| SCHEMBL5239779 | 0.88 | MAPT (0.40) | MEN1KMT2ALMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL5238186 | 0.88 | CYP2C19 (0.43) | MEN1KMT2AALDH1A1MAPTHTT | |
| SCHEMBL5232288 | 0.87 | MAPT (0.41) | MEN1KMT2ALMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL5239862 | 0.87 | SRD5A2 (0.39) | MEN1KMT2ALMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL5235799 | 0.86 | MAPT (0.47) | MEN1KMT2ALMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL5236739 | 0.86 | HTR1A (0.44) | MEN1KMT2AALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL5236546 | 0.86 | USP2 (0.46) | MEN1KMT2AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL5236415 | 0.86 | ADAMTS5 (0.40) | LMNAALDH1A1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL5233064 | 0.85 | L3MBTL1 (0.48) | MEN1KMT2ALMNAALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701946-B1 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI AVENTIS (FR) | 2007-12-19 | — | — | EP | claimed |