Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5238186 | 0.89 | CYP2C19 (0.43) | MAPTALDH1A1CYP2C9CYP2C19MEN1 | |
| SCHEMBL5232288 | 0.88 | MAPT (0.41) | MAPTGLAALDH1A1AKR1C3LMNA | |
| SCHEMBL5239092 | 0.88 | MEN1 (0.41) | MAPTALDH1A1HPGDAKR1C3LMNA | |
| SCHEMBL5236546 | 0.87 | USP2 (0.46) | MAPTALDH1A1CYP2C9HPGDCYP2C19 | |
| SCHEMBL5233064 | 0.86 | L3MBTL1 (0.48) | MAPTALDH1A1AKR1C3LMNASMN1; SMN2 | |
| SCHEMBL5234712 | 0.85 | NOTUM (0.43) | MAPTALDH1A1CYP2C19LMNAGAA | |
| SCHEMBL5237326 | 0.85 | CA2 (0.43) | MAPTAKR1C3LMNASMN1; SMN2MEN1 | |
| SCHEMBL5234836 | 0.85 | MEN1 (0.43) | MAPTGLAALDH1A1CYP2C9HPGD | |
| SCHEMBL5235440 | 0.85 | ALDH1A1 (0.40) | MAPTALDH1A1CYP2C9HPGDCYP2C19 | |
| SCHEMBL5232873 | 0.83 | TSHR (0.44) | MAPTALDH1A1LMNASMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701946-B1 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI AVENTIS (FR) | 2007-12-19 | — | — | EP | claimed |