Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR2 | P30518 | 6/20 | 0.44 |
| ▸ | AVPR1A | P37288 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 8/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8561104 | 0.81 | AVPR2 (0.53) | AVPR2AVPR1AHPGDALDH1A1RAB9A | |
| SCHEMBL5233013 | 0.80 | AVPR2 (0.64) | AVPR2AVPR1AHPGDALDH1A1RAB9A | |
| SCHEMBL7319409 | 0.77 | AVPR2 (0.66) | AVPR2AVPR1AHPGDALDH1A1RAB9A | |
| SCHEMBL5235081 | 0.77 | AVPR2 (0.74) | AVPR2AVPR1A | |
| SCHEMBL5239857 | 0.76 | AVPR1A (0.52) | AVPR2AVPR1AHPGDALDH1A1KMT2A | |
| SCHEMBL8820844 | 0.74 | AVPR2 (0.54) | AVPR2AVPR1AHPGDALDH1A1RAB9A | |
| SCHEMBL19454364 | 0.70 | ALDH1A1 (0.45) | AVPR2AVPR1AHPGDALDH1A1RAB9A | |
| SCHEMBL6985203 | 0.70 | AVPR1A (0.61) | AVPR2AVPR1A | |
| SCHEMBL19454369 | 0.68 | AVPR2 (0.41) | AVPR2AVPR1AALDH1A1RAB9AKMT2A | |
| SCHEMBL9059366 | 0.67 | AVPR2 (0.61) | AVPR2AVPR1AHPGDALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0804440-B1 | TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS | WYETH CORP (US) | 2007-12-19 | — | — | EP | disclosed |
| WO-1996022295-A1 | TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS | AMERICAN CYANAMID COMPANY (US) | 1996-07-25 | — | — | WO | disclosed |
| US-5532235-A | TO TREAT EXCESS RENAL REABSORPTION | AMERICAN CYANAMID COMPANY (US) | 1996-07-02 | — | — | US | disclosed |