SCHEMBL5236677

SCHEMBL5236677

CC(C)(C)OC(N)=O.FC1(C2CC(=S)N(Cc3ccccc3)C2)CCC1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SIRT1 Q96EB6 2/20 0.39
SIRT2 Q8IXJ6 1/20 0.39
KMT2A Q03164 2/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
OPRK1 P41145 2/20 0.35
OPRD1 P41143 1/20 0.35
ALDH1A1 P00352 3/20 0.33
NPFFR1 Q9GZQ6 1/20 0.33
NPFFR2 Q9Y5X5 1/20 0.33
TSHR P16473 1/20 0.33
MAPK1 P28482 1/20 0.33
CYP2D6 P10635 1/20 0.33
OPRM1 P35372 2/20 0.33
SCN9A Q15858 1/20 0.33
BCHE P06276 1/20 0.33
HTR6 P50406 1/20 0.33
PLA2G10 O15496 1/20 0.33
PLA2G5 P39877 1/20 0.33
BRD4 O60885 1/20 0.33
ACE P12821 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5235899 0.73 KMT2A (0.41) SIRT1SIRT2KMT2AL3MBTL1ALDH1A1
SCHEMBL4671695 0.67 KMT2A (0.45) KMT2AL3MBTL1OPRD1ALDH1A1NPFFR1
SCHEMBL4748075 0.67 KMT2A (0.42) SIRT1SIRT2KMT2AL3MBTL1OPRK1
SCHEMBL8399553 0.65 MAPK1 (0.48) KMT2AOPRK1OPRD1ALDH1A1MAPK1
SCHEMBL27595008 0.65 PLA2G10 (0.41) SIRT1SIRT2KMT2AL3MBTL1OPRK1
SCHEMBL5232248 0.65 ALDH1A1 (0.43) KMT2AL3MBTL1OPRD1ALDH1A1TSHR
Ethylbenzene SCHEMBL27571280 0.64 TP53 (0.50) KMT2AALDH1A1TSHR
SCHEMBL7498037 0.64 CTSS (0.41) KMT2AL3MBTL1SCN9ABCHEACE
SCHEMBL7498039 0.64 CTSS (0.41) KMT2AL3MBTL1SCN9ABCHEACE
Trifluoroacetic Acid SCHEMBL4673565 0.64 HPGD (0.45) KMT2AALDH1A1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0990654-B1 SUBSTITUTED CYCLOBUTYLAMINE DERIVATIVES DAIICHI SANKYO CO LTD (JP) 2007-11-14 EP disclosed
US-6448266-B1 COMPOUNDS SUCH AS 2-AMINO-7-(3-(3-AMINO-1-FLUOROCYCLOBUTAN-3-YL)PYRROLIDIN-1-YL)-6-FLUORO-1-(2-FLUORO-1-CYCLOPROPYL)-8-METHYL-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID; ANTIBACTERIAL ACTIVITY; STAPHYLOCOCCUS, PNEUMOCOCCUS DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2002-09-10 US disclosed
EP-0990654-A1 SUBSTITUTED CYCLOBUTYLAMINE DERIVATIVES DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2000-04-05 EP disclosed