Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 3/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 3/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.39 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 2/20 | 0.37 |
| ▸ | ADK | P55263 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ME2 | P23368 | 1/20 | 0.35 |
| ▸ | ME1 | P48163 | 1/20 | 0.35 |
| ▸ | ME3 | Q16798 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5234753 | 0.94 | DGAT1 (0.41) | MGLLEGLN1RAB9ADGAT1KCNH2 | |
| SCHEMBL5231072 | 0.89 | MCHR1 (0.41) | MGLLDGAT1KCNH2PANK3CNR2 | |
| SCHEMBL5238349 | 0.87 | MAPT (0.45) | MGLLDGAT1KCNH2PANK3LMNA | |
| SCHEMBL5235440 | 0.85 | ALDH1A1 (0.40) | LMNAMAPTHTTSMN1; SMN2KMT2A | |
| SCHEMBL5237002 | 0.84 | DGAT1 (0.41) | DGAT1KCNH2CNR2MCHR1 | |
| SCHEMBL5238939 | 0.84 | MCHR1 (0.39) | MCHR1 | |
| SCHEMBL5238522 | 0.84 | PANK3 (0.43) | RAB9APANK3MAPTKMT2A | |
| SCHEMBL5238842 | 0.82 | EGLN1 (0.43) | EGLN1DGAT1KMT2AME2ME1 | |
| SCHEMBL5237578 | 0.81 | KDM4E (0.43) | MGLLDGAT1KCNH2PANK3CNR2 | |
| SCHEMBL5237020 | 0.81 | MGLL (0.47) | MGLLDGAT1KCNH2LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701946-B1 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI AVENTIS (FR) | 2007-12-19 | — | — | EP | claimed |