Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.68 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.68 |
| ▸ | CA12 | O43570 | 1/20 | 0.63 |
| ▸ | CA1 | P00915 | 1/20 | 0.63 |
| ▸ | CA2 | P00918 | 1/20 | 0.63 |
| ▸ | CA9 | Q16790 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.59 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | GLA | P06280 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL632109 | 0.95 | CA12 (0.69) | KMT2AMEN1SLC6A7CA12CA1 | |
| SCHEMBL5239356 | 0.86 | MEN1 (0.68) | KMT2AMEN1SLC6A7LMNAALDH1A1 | |
| SCHEMBL5233832 | 0.83 | LMNA (0.62) | KMT2AMEN1SLC6A7CA12CA2 | |
| SCHEMBL16595411 | 0.82 | CA12 (0.67) | KMT2AMEN1SLC6A7CA12CA1 | |
| SCHEMBL5231928 | 0.82 | CA12 (0.66) | KMT2AMEN1SLC6A7CA12CA2 | |
| SCHEMBL16026460 | 0.82 | CA12 (0.71) | KMT2AMEN1SLC6A7CA12CA1 | |
| SCHEMBL27607283 | 0.82 | AKR1C3 (0.83) | KMT2AMEN1SLC6A7CA12CA1 | |
| SCHEMBL16655737 | 0.80 | SLC6A7 (0.59) | KMT2AMEN1SLC6A7ALDH1A1SMN1; SMN2 | |
| SCHEMBL17801327 | 0.79 | NPC1 (0.73) | KMT2AMEN1CA12CA1CA2 | |
| SCHEMBL5235731 | 0.79 | PANK3 (0.54) | KMT2AMEN1SLC6A7LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701946-B1 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI AVENTIS (FR) | 2007-12-19 | — | — | EP | claimed |