Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.52 |
| ▸ | TRPV1 | Q8NER1 | 9/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | RBP4 | P02753 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | FAAH | O00519 | 1/20 | 0.45 |
| ▸ | TTR | P02766 | 1/20 | 0.45 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5234580 | 0.84 | GAA (0.46) | GAASMN1; SMN2ALDH1A1FAAH | |
| SCHEMBL5237576 | 0.84 | KMT2A (0.53) | GAASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL5232433 | 0.83 | ALDH1A1 (0.59) | AKR1C3GAASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL5235199 | 0.83 | GAA (0.53) | AKR1C3GAASMN1; SMN2RBP4ALDH1A1 | |
| SCHEMBL5239273 | 0.81 | ALDH1A1 (0.60) | AKR1C3ALDH1A1 | |
| SCHEMBL5235922 | 0.80 | HTR1A (0.51) | GAASMN1; SMN2ALDH1A1MAPTFAAH | |
| SCHEMBL5233076 | 0.80 | GAA (0.50) | GAASMN1; SMN2ALDH1A1MAPTFAAH | |
| SCHEMBL31694435 | 0.79 | AKR1C3 (0.60) | AKR1C3TRPV1RBP4TTR | |
| SCHEMBL20818495 | 0.79 | AKR1C3 (0.60) | AKR1C3TRPV1RBP4TTR | |
| SCHEMBL5239407 | 0.79 | MAPT (0.52) | GAASMN1; SMN2ALDH1A1MAPTFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701946-B1 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI AVENTIS (FR) | 2007-12-19 | — | — | EP | claimed |