Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 9/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | PDE1A | P54750 | 1/20 | 0.31 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.31 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.30 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | DRD4 | P21917 | 1/20 | 0.30 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17039118 | 0.73 | HEXA (0.41) | TGFBR1 | |
| SCHEMBL14526752 | 0.71 | LMNA (0.44) | TGFBR1 | |
| SCHEMBL244011 | 0.71 | CCR1 (0.46) | TGFBR1IRAK4THRBMAPK14 | |
| SCHEMBL13459007 | 0.69 | DRD4 (0.46) | NR3C1PGRPDE1APDE1BPDE1C | |
| SCHEMBL14968989 | 0.69 | ADRA2A (0.40) | DYRK1AIRAK4 | |
| SCHEMBL8146301 | 0.68 | TGFBR1 (0.36) | TGFBR1IRAK4THRBMAPK14 | |
| SCHEMBL13830902 | 0.68 | HTR2C (0.46) | TGFBR1 | |
| SCHEMBL17034486 | 0.68 | L3MBTL1 (0.48) | — | |
| SCHEMBL5237393 | 0.68 | PDE10A (0.43) | TGFBR1PDE10ADRD2DRD4DRD3 | |
| SCHEMBL24783953 | 0.67 | CHRNA7 (0.40) | TGFBR1THRBMAPK14DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1543001-B1 | PYRAZOLOPYRIDINE DERIVATIVES AS TGF BETA SIGNAL TRANSDUCTION INHIBITORS FOR THE TREATMENT OF CANCER | LILLY CO ELI (US) | 2007-08-15 | — | — | EP | disclosed |