Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | DGAT1 | O75907 | 6/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5238354 | 0.95 | MAPT (0.40) | KDM4EPOLBDGAT1MGLLKCNH2 | |
| SCHEMBL5233015 | 0.91 | MGLL (0.42) | DGAT1MGLLKCNH2CYP2C9CYP3A4 | |
| SCHEMBL5236774 | 0.89 | CACNA1G (0.39) | MAPT | |
| SCHEMBL5234755 | 0.88 | EGLN1 (0.39) | DGAT1MGLLKCNH2CNR2 | |
| SCHEMBL5238848 | 0.87 | EGLN1 (0.42) | DGAT1CYP2C9CYP3A4ALDH1A1 | |
| SCHEMBL5236239 | 0.86 | SMN1; SMN2 (0.41) | KDM4EPOLBDGAT1MGLLKCNH2 | |
| SCHEMBL5237027 | 0.85 | MGLL (0.44) | DGAT1MGLLKCNH2CYP2C9CYP3A4 | |
| SCHEMBL5238953 | 0.83 | TEK (0.37) | MAPT | |
| SCHEMBL5236758 | 0.83 | EGLN1 (0.40) | DGAT1MGLLKCNH2CNR2 | |
| SCHEMBL5233798 | 0.82 | AKR1C3 (0.36) | KDM4EPOLBSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701946-B1 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI AVENTIS (FR) | 2007-12-19 | — | — | EP | claimed |