Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 4/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5238354 | 0.91 | MAPT (0.40) | SMN1; SMN2HPGDMGLLMAPTKDM4E | |
| SCHEMBL5233588 | 0.89 | DGAT1 (0.41) | SMN1; SMN2MGLLMAPTKDM4ELMNA | |
| SCHEMBL5237586 | 0.86 | KDM4E (0.40) | SMN1; SMN2HPGDMGLLMAPTKDM4E | |
| SCHEMBL5237945 | 0.83 | PANK3 (0.37) | SMN1; SMN2HPGDMAPTCYP2C9MEN1 | |
| SCHEMBL5236231 | 0.83 | MAPT (0.43) | SMN1; SMN2HPGDMGLLMAPTKDM4E | |
| SCHEMBL5233246 | 0.83 | MGLL (0.42) | SMN1; SMN2HPGDMGLLMAPTKDM4E | |
| SCHEMBL5237027 | 0.82 | MGLL (0.44) | MGLLKCNH2DGAT1CYP2C9CYP3A4 | |
| SCHEMBL5238953 | 0.80 | TEK (0.37) | MAPT | |
| SCHEMBL5236758 | 0.79 | EGLN1 (0.40) | MGLLKCNH2DGAT1 | |
| SCHEMBL5233790 | 0.78 | CA2 (0.38) | MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701946-B1 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI AVENTIS (FR) | 2007-12-19 | — | — | EP | claimed |