Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | ILK | Q13418 | 1/20 | 0.47 |
| ▸ | ME2 | P23368 | 1/20 | 0.46 |
| ▸ | ME1 | P48163 | 1/20 | 0.46 |
| ▸ | ME3 | Q16798 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | LDHA | P00338 | 1/20 | 0.45 |
| ▸ | LDHB | P07195 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5238067 | 0.96 | CA12 (0.53) | CA12CA2CA9AKR1C3SMN1; SMN2 | |
| SCHEMBL594530 | 0.90 | ALDH1A1 (0.53) | SMN1; SMN2HPGDLMNAMAPTKDM4E | |
| SCHEMBL5239244 | 0.87 | ALDH1A1 (0.52) | CA12CA2CA9SMN1; SMN2HPGD | |
| SCHEMBL594349 | 0.87 | HRH2 (0.52) | SMN1; SMN2LMNAMAPTKDM4EGAA | |
| SCHEMBL5233512 | 0.86 | MAPT (0.51) | SMN1; SMN2HPGDLMNAMAPTKDM4E | |
| SCHEMBL595310 | 0.85 | SMN1; SMN2 (0.64) | SMN1; SMN2HPGDLMNAMAPTKDM4E | |
| SCHEMBL5236702 | 0.85 | FAAH (0.57) | AKR1C3SMN1; SMN2HPGDLMNAMAPT | |
| SCHEMBL5234744 | 0.83 | ALDH1A1 (0.67) | SMN1; SMN2LMNAMAPTGAAALDH1A1 | |
| SCHEMBL5233900 | 0.83 | ALDH1A1 (0.55) | CA12CA2CA9AKR1C3SMN1; SMN2 | |
| SCHEMBL5235029 | 0.83 | GAA (0.52) | SMN1; SMN2LMNAMAPTKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701946-B1 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI AVENTIS (FR) | 2007-12-19 | — | — | EP | claimed |