Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | MAPT | P10636 | 7/20 | 0.50 |
| ▸ | LMNA | P02545 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5233900 | 0.96 | ALDH1A1 (0.55) | ALDH1A1MAPTLMNAKDM4EGAA | |
| SCHEMBL5233512 | 0.89 | MAPT (0.51) | ALDH1A1MAPTLMNAKDM4EGAA | |
| SCHEMBL5236702 | 0.88 | FAAH (0.57) | ALDH1A1MAPTLMNAKDM4EGAA | |
| SCHEMBL5238043 | 0.87 | CA12 (0.50) | ALDH1A1MAPTLMNAKDM4EGAA | |
| SCHEMBL5235029 | 0.86 | GAA (0.52) | ALDH1A1MAPTLMNAKDM4EGAA | |
| SCHEMBL594349 | 0.85 | HRH2 (0.52) | ALDH1A1MAPTLMNAKDM4EGAA | |
| SCHEMBL5239584 | 0.85 | CD274 (0.45) | ALDH1A1MAPTLMNAKDM4EGAA | |
| SCHEMBL5239162 | 0.85 | MAPT (0.53) | ALDH1A1MAPTLMNAKDM4EGAA | |
| SCHEMBL5235359 | 0.85 | MAPT (0.58) | ALDH1A1MAPTLMNAKDM4EGAA | |
| SCHEMBL5237096 | 0.84 | MAPT (0.69) | ALDH1A1MAPTLMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701946-B1 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI AVENTIS (FR) | 2007-12-19 | — | — | EP | claimed |