Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PANK3 | Q9H999 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.34 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.34 |
| ▸ | DHFR | P00374 | 1/20 | 0.34 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | DRD1 | P21728 | 2/20 | 0.33 |
| ▸ | DRD5 | P21918 | 2/20 | 0.33 |
| ▸ | DRD3 | P35462 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5237945 | 0.90 | PANK3 (0.37) | PANK3PPARGPPARARAB9AL3MBTL1 | |
| SCHEMBL5233815 | 0.86 | PANK3 (0.35) | PANK3PPARGPPARARAB9AL3MBTL1 | |
| SCHEMBL5237467 | 0.85 | PANK3 (0.40) | PANK3HDAC1AOC3KMT2AHRH3 | |
| SCHEMBL5236758 | 0.85 | EGLN1 (0.40) | PANK3RAB9ADRD2 | |
| SCHEMBL5235197 | 0.84 | HSD17B10 (0.45) | CYP1A2CYP2C19HTR1AMAPTCYP2C9 | |
| SCHEMBL5239788 | 0.83 | MAPT (0.43) | RAB9AL3MBTL1CYP2C19KMT2AMAPT | |
| SCHEMBL5238354 | 0.83 | MAPT (0.40) | CYP1A2CYP2C19KMT2AMAPTMEN1 | |
| SCHEMBL5233798 | 0.82 | AKR1C3 (0.36) | PANK3PPARGPPARARAB9AHDAC1 | |
| SCHEMBL5231485 | 0.82 | HTR3A (0.44) | HDAC1DRD2DRD3HTR1AHTR2A | |
| SCHEMBL5237297 | 0.82 | KDM4E (0.40) | L3MBTL1HRH3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701946-B1 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI AVENTIS (FR) | 2007-12-19 | — | — | EP | claimed |