Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.45 |
| ▸ | HPGD | P15428 | 5/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 4/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5237297 | 0.85 | KDM4E (0.40) | KDM4ETHRBALDH1A1MAPT | |
| SCHEMBL5238192 | 0.84 | CYP2C19 (0.37) | HSD17B10CYP2C9CYP3A4NPSR1ALDH1A1 | |
| SCHEMBL5238526 | 0.84 | PANK3 (0.39) | CYP2C9CYP2C19CYP1A2HTR1AMAPT | |
| SCHEMBL5231485 | 0.83 | HTR3A (0.44) | ALDH1A1TSHRHTR1A | |
| SCHEMBL5238157 | 0.82 | KDM4E (0.48) | HSD17B10KDM4EHPGDCYP3A4RECQL | |
| SCHEMBL5236555 | 0.80 | USP2 (0.41) | HSD17B10HPGDCYP2C9CYP3A4ALDH1A1 | |
| SCHEMBL5235916 | 0.80 | AR (0.40) | KDM4ECYP2C9ALDH1A1TSHRCYP2C19 | |
| SCHEMBL5237871 | 0.80 | DRD2 (0.40) | ALDH1A1HTR1AMAPT | |
| SCHEMBL5238575 | 0.78 | CXCR3 (0.38) | HTR1A | |
| SCHEMBL5238354 | 0.78 | MAPT (0.40) | KDM4EHPGDCYP2C9CYP3A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701946-B1 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI AVENTIS (FR) | 2007-12-19 | — | — | EP | claimed |