Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PANK3 | Q9H999 | 3/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | SMO | Q99835 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | AOC3 | Q16853 | 3/20 | 0.33 |
| ▸ | CACNA1H | O95180 | 5/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.31 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.31 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5238526 | 0.85 | PANK3 (0.39) | PANK3HDAC1AOC3CACNA1HMEN1 | |
| SCHEMBL5237457 | 0.81 | PANK3 (0.41) | PANK3RORCSMOHDAC1AOC3 | |
| SCHEMBL5236758 | 0.81 | EGLN1 (0.40) | PANK3 | |
| SCHEMBL5237148 | 0.81 | RORC (0.34) | RORCAOC3HRH3 | |
| SCHEMBL5235197 | 0.80 | HSD17B10 (0.45) | — | |
| SCHEMBL5237176 | 0.79 | NPC1 (0.35) | HDAC1MEN1KMT2A | |
| SCHEMBL5238354 | 0.79 | MAPT (0.40) | MEN1KMT2A | |
| SCHEMBL5231485 | 0.78 | HTR3A (0.44) | HDAC1 | |
| SCHEMBL5233798 | 0.78 | AKR1C3 (0.36) | PANK3HDAC1AOC3 | |
| SCHEMBL5237297 | 0.78 | KDM4E (0.40) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701946-B1 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI AVENTIS (FR) | 2007-12-19 | — | — | EP | claimed |