Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.47 |
| ▸ | ERN1 | O75460 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | ME2 | P23368 | 2/20 | 0.44 |
| ▸ | ME1 | P48163 | 2/20 | 0.44 |
| ▸ | ME3 | Q16798 | 2/20 | 0.44 |
| ▸ | CTSA | P10619 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5237607 | 0.84 | KDM4E (0.47) | GRM5MAPTKDM4EALDH1A1GAA | |
| SCHEMBL5259717 | 0.82 | MAPT (0.60) | GRM5MAPTKDM4EALDH1A1GAA | |
| SCHEMBL5234829 | 0.81 | GRM5 (0.54) | GRM5MAPTKDM4EALDH1A1GAA | |
| SCHEMBL5237364 | 0.81 | TP53 (0.49) | MAPTALDH1A1GAAMEN1KMT2A | |
| SCHEMBL23573654 | 0.79 | GRM5 (0.53) | GRM5MAPTALDH1A1GAAS1PR5 | |
| SCHEMBL5236266 | 0.78 | MAPT (0.41) | MAPTKDM4EALDH1A1GAATDP1 | |
| SCHEMBL2767656 | 0.78 | KDM4E (0.46) | GRM5MAPTKDM4EALDH1A1GAA | |
| SCHEMBL31181068 | 0.78 | TLR9 (0.51) | MAPTKDM4EALDH1A1GAATDP1 | |
| SCHEMBL5261930 | 0.78 | TLR9 (0.51) | MAPTKDM4EALDH1A1GAATDP1 | |
| SCHEMBL16874653 | 0.77 | S1PR5 (0.47) | MAPTALDH1A1S1PR5ERN1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701946-B1 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI AVENTIS (FR) | 2007-12-19 | — | — | EP | claimed |