Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | ERN1 | O75460 | 1/20 | 0.41 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 2/20 | 0.37 |
| ▸ | CTSA | P10619 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.37 |
| ▸ | PPARD | Q03181 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5236699 | 0.86 | CD274 (0.41) | MAPTALDH1A1HTR6FFAR1MAPK1 | |
| SCHEMBL5236205 | 0.86 | RXRA (0.41) | MAPTKDM4EALDH1A1GAATDP1 | |
| SCHEMBL5236271 | 0.84 | ERN1 (0.43) | MAPTKDM4EALDH1A1GAATDP1 | |
| SCHEMBL5236546 | 0.81 | USP2 (0.46) | MAPTALDH1A1MAPK1USP2KMT2A | |
| SCHEMBL5232202 | 0.79 | RAB9A (0.40) | MAPTKDM4EALDH1A1GAATDP1 | |
| SCHEMBL5238577 | 0.78 | GRM5 (0.50) | MAPTKDM4EALDH1A1GAATDP1 | |
| SCHEMBL5238186 | 0.77 | CYP2C19 (0.43) | MAPTALDH1A1MAPK1USP2KMT2A | |
| SCHEMBL5240792 | 0.76 | NAAA (0.42) | MAPTALDH1A1MAPK1RAB9ALMNA | |
| SCHEMBL5238647 | 0.76 | USP2 (0.50) | ALDH1A1MAPK1USP2KMT2A | |
| SCHEMBL5232288 | 0.76 | MAPT (0.41) | MAPTKDM4EALDH1A1GAAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701946-B1 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI AVENTIS (FR) | 2007-12-19 | — | — | EP | claimed |