Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | GRM5 | P41594 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | ERN1 | O75460 | 1/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
| ▸ | HRH2 | P25021 | 1/20 | 0.41 |
| ▸ | HTR1B | P28222 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5239584 | 0.86 | CD274 (0.45) | KDM4EMAPTALDH1A1GAATDP1 | |
| SCHEMBL5234008 | 0.85 | GRM5 (0.47) | KDM4EMAPTALDH1A1GAATDP1 | |
| SCHEMBL5238577 | 0.84 | GRM5 (0.50) | KDM4EMAPTALDH1A1GAATDP1 | |
| SCHEMBL5233512 | 0.82 | MAPT (0.51) | KDM4EMAPTALDH1A1GAAMAPK1 | |
| SCHEMBL5239244 | 0.79 | ALDH1A1 (0.52) | KDM4EMAPTALDH1A1GAAGRM5 | |
| SCHEMBL5236270 | 0.79 | KMT2A (0.49) | KDM4EMAPTALDH1A1GAATDP1 | |
| SCHEMBL5239407 | 0.78 | MAPT (0.52) | KDM4EMAPTALDH1A1GAAGRM5 | |
| SCHEMBL5238583 | 0.77 | HSD17B10 (0.57) | MAPTALDH1A1MAPK1MEN1KMT2A | |
| SCHEMBL5233900 | 0.76 | ALDH1A1 (0.55) | KDM4EMAPTALDH1A1GAAGRM5 | |
| SCHEMBL5233951 | 0.76 | MAPT (0.47) | KDM4EMAPTALDH1A1GAAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701946-B1 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI AVENTIS (FR) | 2007-12-19 | — | — | EP | claimed |