Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 known ✓ | P20309 | 13/20 | 0.50 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.49 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.49 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.49 |
| ▸ | HRH1 | P35367 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.49 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2596487 | 0.77 | KEAP1 (0.50) | CHRM3CHRM2KCNH2CHRM4CHRM5 | |
| SCHEMBL17871674 | 0.76 | ALDH1A1 (0.52) | CHRM3CHRM2CHRM1KEAP1NFE2L2 | |
| Bromomethane SCHEMBL19839345 | 0.74 | ALDH1A1 (0.50) | CHRM3CHRM2CHRM1KEAP1NFE2L2 | |
| SCHEMBL4967978 | 0.71 | ALDH1A1 (0.46) | CHRM3CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL6590742 | 0.71 | KEAP1 (0.43) | CHRM3CHRM2CHRM1KEAP1NFE2L2 | |
| SCHEMBL6593469 | 0.70 | KEAP1 (0.63) | CHRM3CHRM2KCNH2CHRM4CHRM5 | |
| SCHEMBL4189381 | 0.70 | KEAP1 (0.51) | CHRM3CHRM2KCNH2CHRM1KEAP1 | |
| SCHEMBL4076900 | 0.70 | KEAP1 (0.58) | CHRM3CHRM2KCNH2CHRM4CHRM5 | |
| SCHEMBL6589288 | 0.69 | GPR119 (0.49) | — | |
| SCHEMBL5701311 | 0.69 | KEAP1 (0.61) | CHRM3CHRM2KCNH2CHRM1KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8969350-B2 | Pharmaceutical product comprising a p38 kinase inhibitor and a second active ingredient | ASTRAZENECA AB (SE) | 2015-03-03 | — | — | US | disclosed |
| US-20120028941-A1 | Pharmaceutical Product Comprising a P38 Kinase Inhibitor and a Second Active Ingredient | ASTRAZENECA UK LIMITED (GB) | 2012-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028941-A1 | Pharmaceutical Product Comprising a P38 Kinase Inhibitor and a Second Active Ingredient | NR3C2, ARRB1, GRK4 | CHRM3 654/4885CHRM1 1204/4885CHRM2 1149/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.