Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | BRD2 | P25440 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
| ▸ | TOP1 | P11387 | 1/20 | 0.31 |
| ▸ | TOP2A | P11388 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | PIM1 | P11309 | 1/20 | 0.30 |
| ▸ | ATR | Q13535 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5213968 | 0.81 | MAPT (0.55) | MAPTALDH1A1LMNAMAPK1GFER | |
| SCHEMBL5622837 | 0.80 | ALDH1A1 (0.41) | MAPTMAOAPDE3BPDE3AALDH1A1 | |
| SCHEMBL5244666 | 0.80 | ALDH1A1 (0.47) | MAPTALDH1A1LMNATOP1L3MBTL1 | |
| SCHEMBL17144408 | 0.78 | MAPT (0.51) | MAPTALDH1A1MAPK1GFERKDM4E | |
| SCHEMBL5212713 | 0.75 | MAOA (0.69) | MAOALMNA | |
| SCHEMBL216385 | 0.72 | MAPT (0.59) | MAPTBRD4BRD2ALDH1A1LMNA | |
| SCHEMBL5243119 | 0.72 | MAOA (0.57) | MAOALMNA | |
| SCHEMBL5246863 | 0.72 | ALDH1A1 (0.38) | MAPTDPP4MAOAPDE3BPDE3A | |
| SCHEMBL5245062 | 0.71 | KDM4E (0.36) | DPP4ALDH1A1MAPK1KDM4EL3MBTL1 | |
| SCHEMBL17422290 | 0.71 | CASP6 (0.54) | MAPTALDH1A1LMNAGFERBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1819699-A2 | DIAZEPINE OXAZOLIDINONES AS ANTIBACTERIAL AGENTS | Pharmacia & Upjohn Company LLC (US) | 2007-08-22 | — | — | EP | disclosed |
| WO-2006056877-A2 | DIAZEPINE OXAZOLIDINONES AS ANTIBACTERIAL AGENTS | PHARMACIA & UPJOHN COMPANY LLC (US) | 2006-06-01 | — | — | WO | disclosed |