Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MC4R | P32245 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | FABP3 | P05413 | 1/20 | 0.34 |
| ▸ | FABP4 | P15090 | 1/20 | 0.34 |
| ▸ | PRNP | P04156 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.34 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27685125 | 0.87 | MCHR1 (0.38) | MCHR1ALDH1A1TP53MC4ROPRM1 | |
| SCHEMBL2828012 | 0.85 | ALDH1A1 (0.41) | MCHR1ALDH1A1TP53MC4ROPRM1 | |
| SCHEMBL27685002 | 0.82 | MCHR1 (0.39) | MCHR1ALDH1A1OPRM1OPRD1OPRK1 | |
| SCHEMBL27685121 | 0.80 | PSIP1 (0.39) | MCHR1ALDH1A1TP53OPRM1OPRD1 | |
| SCHEMBL2821958 | 0.80 | FABP3 (0.43) | MCHR1ALDH1A1FABP3FABP4PRNP | |
| SCHEMBL27685274 | 0.78 | HSD11B1 (0.36) | MCHR1ALDH1A1 | |
| SCHEMBL2825540 | 0.76 | ALDH1A1 (0.39) | MCHR1ALDH1A1FABP3FABP4PRNP | |
| SCHEMBL27685000 | 0.74 | PSIP1 (0.40) | MCHR1ALDH1A1OPRM1OPRD1OPRK1 | |
| SCHEMBL27704121 | 0.71 | IDO1 (0.43) | ALDH1A1TP53CASP3MAPT | |
| SCHEMBL27685273 | 0.71 | PSIP1 (0.37) | MCHR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1809605-A1 | QUINOLINE AS ALLOSTERIC ENHANCERS OF THE GABA-B RECEPTORS | F. Hoffmann-Roche AG (CH) | 2007-07-25 | — | — | EP | disclosed |
| WO-2006048146-A1 | QUINOLINE AS ALLOSTERIC ENHANCERS OF THE GABA-B RECEPTORS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-05-11 | — | — | WO | disclosed |