Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5239789 | 0.93 | FAAH (0.51) | FAAHALDH1A1KDM4EPOLBHTT | |
| SCHEMBL27659208 | 0.84 | FAAH (0.48) | FAAHALDH1A1KDM4EPOLBHTT | |
| SCHEMBL27681399 | 0.81 | FAAH (0.44) | FAAHALDH1A1KDM4EPOLBHTT | |
| SCHEMBL593633 | 0.81 | USP2 (0.47) | FAAHALDH1A1HTTSMN1; SMN2MAPT | |
| SCHEMBL27679302 | 0.81 | FAAH (0.46) | FAAHALDH1A1KDM4EPOLBHTT | |
| SCHEMBL13793796 | 0.81 | TSHR (0.61) | FAAHALDH1A1POLBHTTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL594772 | 0.79 | FAAH (0.45) | FAAHALDH1A1KDM4EPOLBHTT | |
| SCHEMBL5239407 | 0.79 | MAPT (0.52) | FAAHALDH1A1KDM4EPOLBHTT | |
| SCHEMBL594439 | 0.79 | FAAH (0.38) | FAAH | |
| SCHEMBL6062744 | 0.77 | ALDH1A1 (0.62) | ALDH1A1KDM4EPOLBHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100567279-C | Alkylpiperazine-and alkylpiperazine-carboxylate derivatives, method for the production thereof and use thereof as FAAH enzyme inhibitors | SANOFI AVENTIS (FR) | 2009-12-09 | — | — | CN | disclosed |
| EP-1701946-B1 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI AVENTIS (FR) | 2007-12-19 | — | — | EP | disclosed |
| CN-1922162-A | Alkylpiperazine-and alkylpiperazine-carboxylate derivatives, method for the production thereof and use thereof as FAAH enzyme inhibitors | SANOFI AVENTIS (FR) | 2007-02-28 | — | — | CN | disclosed |
| EP-1701946-A2 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | Sanofi-Aventis (FR) | 2006-09-20 | — | — | EP | disclosed |
| WO-2005070910-A2 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI-AVENTIS (FR) | 2005-08-04 | — | — | WO | disclosed |