Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | GBA1 | P04062 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL38661570 | 1.00 | USP2 (0.51) | USP2TP53HTTLMNASMN1; SMN2 | |
| SCHEMBL5240146 | 0.84 | RAB9A (0.57) | TP53SMN1; SMN2NPC1RAB9AGBA1 | |
| SCHEMBL2801582 | 0.83 | P2RX7 (0.53) | LMNASMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL5235569 | 0.82 | P2RX7 (0.49) | TP53HTTLMNASMN1; SMN2NPC1 | |
| SCHEMBL5956440 | 0.82 | WNT3A (0.43) | HTTLMNANPC1RAB9AMAPT | |
| SCHEMBL5235128 | 0.79 | ALOX5 (0.49) | MAPTP2RX7MEN1KMT2AL3MBTL1 | |
| SCHEMBL5234383 | 0.78 | P2RX7 (0.45) | SMN1; SMN2NPC1RAB9AP2RX7MEN1 | |
| SCHEMBL38661938 | 0.78 | SMN1; SMN2 (0.63) | USP2TP53HTTLMNASMN1; SMN2 | |
| SCHEMBL5232062 | 0.78 | SMN1; SMN2 (0.63) | USP2TP53HTTLMNASMN1; SMN2 | |
| SCHEMBL11876573 | 0.77 | MAPT (0.50) | HTTLMNASMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397364-B1 | NOVEL PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | LILLY CO ELI (US) | 2007-07-25 | — | — | EP | disclosed |