Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.46 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.46 |
| ▸ | ABAT | P80404 | 1/20 | 0.46 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2391793 | 0.88 | ALDH1A1 (0.46) | KMT2AALDH1A1TSHRHPGDMAPT | |
| SCHEMBL96635 | 0.86 | ALDH1A1 (0.59) | KMT2AALDH1A1TSHRHPGDMAPT | |
| SCHEMBL16619850 | 0.86 | ALDH1A1 (0.59) | KMT2AALDH1A1TSHRHPGDMAPT | |
| Hydrochloric Acid SCHEMBL23711567 | 0.84 | ALDH1A1 (0.57) | KMT2AALDH1A1TSHRHPGDMAPT | |
| SCHEMBL4909672 | 0.82 | ALDH1A1 (0.52) | KMT2AALDH1A1TSHRHPGDMAPT | |
| SCHEMBL13221149 | 0.82 | ALDH1A1 (0.53) | KMT2AALDH1A1HPGDMAPTTDP1 | |
| SCHEMBL19628274 | 0.81 | ALDH1A1 (0.50) | KMT2AALDH1A1TSHRHPGDMAPT | |
| SCHEMBL15771884 | 0.81 | ALDH1A1 (0.51) | KMT2AALDH1A1HPGDMAPTTDP1 | |
| SCHEMBL4008475 | 0.81 | TTR (0.60) | KMT2AALDH1A1TSHRHPGDMAPT | |
| SCHEMBL2650454 | 0.81 | ALDH1A1 (0.48) | KMT2AALDH1A1TSHRHPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 102 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114539249-B | Podophyllotoxin derivative tubulin inhibitor, and preparation method and medical application thereof | 中国药科大学 | 2024-01-26 | — | — | CN | disclosed |
| CN-114539249-A | Podophyllotoxin derivative tubulin inhibitor and preparation method and medical application thereof | 中国药科大学 | 2022-05-27 | — | — | CN | disclosed |
| EP-2544679-B1 | PDE10 INHIBITORS AND RELATED COMPOSITIONS AND METHODS | OMEROS CORP (US) | 2019-05-15 | — | — | EP | disclosed |
| EP-2544679-B1 | PDE10 INHIBITORS AND RELATED COMPOSITIONS AND METHODS | OMEROS CORP (US) | 2019-05-15 | — | — | EP | disclosed |
| US-10287226-B2 | Mild catalytic reduction of C—O bonds and C═O bonds using a recyclable catalyst system | ORGANOFUEL SWEDEN AB (SE) | 2019-05-14 | — | — | US | disclosed |
| US-10106516-B2 | PDE10 inhibitors and related compositions and methods | OMEROS CORPORATION (US) | 2018-10-23 | — | — | US | disclosed |
| US-20170334819-A1 | A MILD CATALYTIC REDUCTION OF C-O BONDS AND C=O BONDS USING A RECYCLABLE CATALYST SYSTEM | ORGANOFUEL SWEDEN AB (SE) | 2017-11-23 | — | — | US | disclosed |
| EP-2794620-B1 | BODIPY STRUCTURE FLUORESCENCE PROBES FOR DIVERSE BIOLOGICAL APPLICATIONS | NAT UNIV SINGAPORE (SG) | 2017-11-15 | — | — | EP | disclosed |
| US-20170152238-A1 | PDE10 INHIBITORS AND RELATED COMPOSITIONS AND METHODS | OMEROS CORPORATION | 2017-06-01 | — | — | US | disclosed |
| US-20170152238-A1 | PDE10 INHIBITORS AND RELATED COMPOSITIONS AND METHODS | OMEROS CORPORATION | 2017-06-01 | — | — | US | disclosed |
| US-6248743-B1 | ANTITHROMBOTIC AGENTS EFFECTIVE TO INHIBIT THE PRODUCTION OF TYPE 1 PLASMINOGEN ACTIVATOR INHIBITOR (PAI-1) | TANABE SEIYAKU CO., LTD. (JP) | 2001-06-19 | — | — | US | disclosed |
| WO-2001034591-A2 | SUBSTITUTED 4H-CHROMENE AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF | CYTOVIA, INC. (US) | 2001-05-17 | — | — | WO | disclosed |
| CN-1214678-A | Butadiene derivatives and process for preparing thereof | TANABE SEIYAKU CO (JP) | 1999-04-21 | — | — | CN | disclosed |
| EP-0889879-A1 | BUTADIENE DERIVATIVES AND PROCESS FOR PREPARING THEREOF | TANABE SEIYAKU CO., LTD. (JP) | 1999-01-13 | — | — | EP | disclosed |
| WO-1997036864-A1 | BUTADIENE DERIVATIVES AND PROCESS FOR PREPARING THEREOF | TANABE SEIYAKU CO., LTD. (JP) | 1997-10-09 | — | — | WO | disclosed |
| US-5446194-A | Pharmacologically active catechol derivatives | ORION-YHTYMA OY (FI) | 1995-08-29 | — | — | US | disclosed |
| US-5283352-A | Transferase inhibitor | ORION-YHTYMA OY (FI) | 1994-02-01 | — | — | US | disclosed |
| US-5112861-A | Inhibitors of catechol-methyl-transferase enzyme, levodopa | ORION-YHTYMA OY (FI) | 1992-05-12 | — | — | US | disclosed |
| EP-0346367-A1 | ARYL- AND ARYLOXY-SUBSTITUTED TERT.-ALKYLENAMINES, PROCESS FOR THEIR MANUFACTURE AND THEIR USE IN PHARMACY | SCHERING AKTIENGESELLSCHAFT (DE) | 1989-12-20 | — | — | EP | disclosed |
| WO-1988006580-A1 | ARYL- AND ARYLOXY-SUBSTITUTED TERT.-ALKYLENAMINES, PROCESS FOR THEIR MANUFACTURE AND THEIR USE IN PHARMACY | SCHERING AKTIENGESELLSCHAFT (DE) | 1988-09-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10106516-B2 | PDE10 inhibitors and related compositions and methods | PDE10A, PDE9A, PDE7A | KMT2A 2449/4885ALDH1A1 2053/4885TSHR 2134/4885 |
| US-20170334819-A1 | A MILD CATALYTIC REDUCTION OF C-O BONDS AND C=O BONDS USING A RECYCLABLE CATALYST SYSTEM | CBR1, ADH1C, AOC2 | KMT2A 943/4885ALDH1A1 198/4885TSHR 4190/4885 |
| US-20170152238-A1 | PDE10 INHIBITORS AND RELATED COMPOSITIONS AND METHODS | PDE10A, PDE9A, PDE7A | KMT2A 2449/4885ALDH1A1 2053/4885TSHR 2134/4885 |
| US-10287226-B2 | Mild catalytic reduction of C—O bonds and C═O bonds using a recyclable catalyst system | CBR1, ADH1C, CBR3 | KMT2A 804/4885ALDH1A1 230/4885TSHR 4092/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.