Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.44 |
| ▸ | DNASE1 | P24855 | 1/20 | 0.44 |
| ▸ | FEN1 | P39748 | 1/20 | 0.44 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5243499 | 0.93 | KMT2A (0.48) | POLBERCC1DNASE1FEN1ERCC4 | |
| SCHEMBL5243149 | 0.87 | RAB9A (0.48) | POLBERCC1DNASE1FEN1ERCC4 | |
| SCHEMBL5240132 | 0.86 | RAB9A (0.47) | POLBERCC1DNASE1FEN1ERCC4 | |
| SCHEMBL5240605 | 0.85 | RAB9A (0.46) | POLBERCC1DNASE1FEN1ERCC4 | |
| SCHEMBL5242591 | 0.84 | MPO (0.49) | POLBERCC1DNASE1FEN1ERCC4 | |
| SCHEMBL5242487 | 0.82 | ERCC1 (0.49) | POLBERCC1DNASE1FEN1ERCC4 | |
| SCHEMBL14339577 | 0.82 | ERCC1 (0.49) | POLBERCC1DNASE1FEN1ERCC4 | |
| SCHEMBL5243422 | 0.81 | ERCC1 (0.46) | POLBERCC1DNASE1FEN1ERCC4 | |
| SCHEMBL5244668 | 0.81 | ERCC1 (0.46) | POLBERCC1DNASE1FEN1ERCC4 | |
| SCHEMBL5242189 | 0.81 | HTR7 (0.55) | GLAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115644-B2 | Heterocyclic compounds | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2006-10-03 | — | — | US | claimed |
| EP-1539708-B1 | BENZIMIDAZOLONES AND THEIR USE AS CYTOKINE INHIBITORS | BOEHRINGER INGELHEIM PHARMA (US) | 2007-12-26 | — | — | EP | disclosed |
| EP-1539708-B1 | BENZIMIDAZOLONES AND THEIR USE AS CYTOKINE INHIBITORS | BOEHRINGER INGELHEIM PHARMA (US) | 2007-12-26 | — | — | EP | disclosed |
| US-7115644-B2 | Heterocyclic compounds | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2006-10-03 | — | — | US | disclosed |