Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC1 | P07992 | 1/20 | 0.46 |
| ▸ | DNASE1 | P24855 | 1/20 | 0.46 |
| ▸ | FEN1 | P39748 | 1/20 | 0.46 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | MPO | P05164 | 3/20 | 0.43 |
| ▸ | CCR4 | P51679 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.41 |
| ▸ | PRKCB | P05771 | 1/20 | 0.40 |
| ▸ | PRKCA | P17252 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5242591 | 0.93 | MPO (0.49) | ERCC1DNASE1FEN1ERCC4APP | |
| SCHEMBL5243149 | 0.84 | RAB9A (0.48) | ERCC1DNASE1FEN1ERCC4APP | |
| SCHEMBL14339577 | 0.84 | ERCC1 (0.49) | ERCC1DNASE1FEN1ERCC4APP | |
| SCHEMBL5242487 | 0.84 | ERCC1 (0.49) | ERCC1DNASE1FEN1ERCC4APP | |
| SCHEMBL5240132 | 0.83 | RAB9A (0.47) | ERCC1DNASE1FEN1ERCC4APP | |
| SCHEMBL5243499 | 0.83 | KMT2A (0.48) | ERCC1DNASE1FEN1ERCC4APP | |
| SCHEMBL5243422 | 0.83 | ERCC1 (0.46) | ERCC1DNASE1FEN1ERCC4APP | |
| SCHEMBL14339630 | 0.82 | PGR (0.45) | ERCC1DNASE1FEN1ERCC4MPO | |
| SCHEMBL5240605 | 0.82 | RAB9A (0.46) | ERCC1DNASE1FEN1ERCC4APP | |
| SCHEMBL5242811 | 0.81 | POLB (0.51) | ERCC1DNASE1FEN1ERCC4APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115644-B2 | Heterocyclic compounds | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2006-10-03 | — | — | US | claimed |
| EP-1539708-B1 | BENZIMIDAZOLONES AND THEIR USE AS CYTOKINE INHIBITORS | BOEHRINGER INGELHEIM PHARMA (US) | 2007-12-26 | — | — | EP | disclosed |
| EP-1539708-B1 | BENZIMIDAZOLONES AND THEIR USE AS CYTOKINE INHIBITORS | BOEHRINGER INGELHEIM PHARMA (US) | 2007-12-26 | — | — | EP | disclosed |
| US-7115644-B2 | Heterocyclic compounds | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2006-10-03 | — | — | US | disclosed |